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单词 allostery
释义

allostery in British English

(əˈlɒstərɪ)
noun
the condition of a protein (such as an enzyme) in which the structure and activity of the enzyme are modified by the binding of a metabolic molecule at a site other than the chemically active one

Examples of 'allostery' in a sentence
allostery

Using a network-based formalism of allostery, we introduced a community-hopping model of allosteric communication.
Gabrielle Stetz, Gennady M Verkhivker 2017, 'Computational Analysis of Residue Interaction Networks and Coevolutionary Relationshipsin the Hsp70 Chaperones: A Community-Hopping Model of Allosteric Regulation and Communication.',PLoS Computational Biologyhttp://europepmc.org/articles/PMC5240922?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we provide an introduction to the investigation of protein allostery using molecular dynamics simulation.
Samuel Hertig, Naomi R Latorraca, Ron O Dror 2016, 'Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations.',PLoS Computational Biologyhttp://europepmc.org/articles/PMC4902200?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we review fundamental principles of photoreceptors and light-regulated allostery.
Thea eZiegler, Thea eZiegler, Andreas eMöglich, Andreas eMöglich 2015, 'Photoreceptor engineering', Frontiers in Molecular Bioscienceshttp://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00030/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Many fundamental cellular processes such as gene expression are tightly regulated by protein allostery.
Wolfram Stacklies, Fei Xia, Frauke Gräter 2009, 'Dynamic allostery in the methionine repressor revealed by force distribution analysis.',PLoS Computational Biologyhttp://europepmc.org/articles/PMC2775130?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our study therefore reveals significant features of the mechanistic basis for allostery.
Thomas L Rodgers, Philip D Townsend, David Burnell, Matthew L Jones, Shane A Richards,Tom C B McLeish, Ehmke Pohl, Mark R Wilson, Martin J Cann 2013, 'Modulation of global low-frequency motions underlies allosteric regulation: demonstrationin CRP/FNR family transcription factors.', PLoS Biologyhttp://europepmc.org/articles/PMC3769225?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The latter we demonstrate as a new exemplar for allostery without conformation change.
Thomas L Rodgers, Philip D Townsend, David Burnell, Matthew L Jones, Shane A Richards,Tom C B McLeish, Ehmke Pohl, Mark R Wilson, Martin J Cann 2013, 'Modulation of global low-frequency motions underlies allosteric regulation: demonstrationin CRP/FNR family transcription factors.', PLoS Biologyhttp://europepmc.org/articles/PMC3769225?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Regions distal to orthosteric sites indicate long range conformational changes with implications for allostery.
Arun Chandramohan, Srinath Krishnamurthy, Srinath Krishnamurthy, Andreas Larsson,Paer Nordlund, Anna Jansson, Ganesh S Anand 2016, 'Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions:Implications for Fragment-Based Drug Design.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4890749?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Conformational changes drive protein function, including catalysis, allostery and signaling.
Ariana Peck, Frédéric Poitevin, Thomas J. Lane 2018, 'Intermolecular correlations are necessary to explain diffuse scattering from proteincrystals', IUCrJhttp://scripts.iucr.org/cgi-bin/paper?S2052252518001124. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The concept of allostery has evolved in the past century.
Jin Liu, Ruth Nussinov 2016, 'Allostery: An Overview of Its History, Concepts, Methods, and Applications.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4890769?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Comparison with other related enzymes shows that similar conformational variability and, byimplication, allostery also exist in other papain-like endopeptidases.
Marko Novinec 2017, 'Computational investigation of conformational variability and allostery in cathepsinK and other related peptidases', PLOS ONE10.1371/journal.pone.0182387. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
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更新时间：2025/2/14 12:09:18