the inability to synthesize particular growth factors, due to mutational changes
Examples of 'auxotrophy' in a sentence
auxotrophy
Arginine auxotrophy however renders these tumors vulnerable to treatment with arginine-degrading enzymes.
Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, TomasFiedler, Christian Junghanss, Claudia Maletzki 2018, 'Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-RefractoryMalignancies', Cellular Physiology and Biochemistryhttps://www.karger.com/Article/FullText/495382. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These phenotypes included colony morphology, motility, quorum sensing, protease activity, auxotrophy, siderophore levels, antibiotic resistance, and growth profiles.
Matthew L. Workentine, Christopher D. Sibley, Bryan Glezerson, Swathi Purighalla,Jens C. Norgaard-Gron, Michael D. Parkins, Harvey R. Rabin, Michael G. Surette 2013, 'Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic FibrosisPatient', PLoS ONE10.1371/journal.pone.0060225. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Scs3p was initially identified because deletion leads to inositol auxotrophy, with an unusual sensitivity to addition of choline.
Matthew J Hayes, Vineet Choudhary, Namrata Ojha, John JH Shin, Gil-Soo Han, GeorgeM. Carman, Christopher JR Loewen, William A Prinz, Timothy P Levine 2017, 'Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferaseenzymes', Microbial Cellhttp://microbialcell.com/researcharticles/fat-storage-inducing-transmembrane-fit-or-fitm-proteins-are-related-to-lipid-phosphatase-phosphotransferase-enzymes/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In biotin-prototrophic fungi, peroxisome-deficient mutants exhibit growth defects when grown on glucose as a carbon source due to biotin auxotrophy.
Jun-ichi eMARUYAMA, Katsuhiko eKITAMOTO 2013, 'Expanding functional repertoires of fungal peroxisomes: contribution to growth andsurvival processes', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2013.00177/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Development of a counter-selection method for phenylalanine auxotrophy could be a useful tool in the repertoire of yeast genetics.
Ian S. Murdoch, Samantha L. Powers, Aaron Z. Welch 2018, 'Fluorinated Phenylalanine Precursor Resistance in Yeast', Fermentationhttp://www.mdpi.com/2311-5637/4/2/41. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cancer cells have specific nutrient(s) auxotrophy and have a much higher nutrient demand compared to normal tissues.
Marcus Kwong Lam Fung, Godfrey Chi-Fung Chan 2017, 'Drug-induced amino acid deprivation as strategy for cancer therapy', Journal of Hematology & Oncologyhttp://link.springer.com/article/10.1186/s13045-017-0509-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To compensate for their amino acid auxotrophy, lactobacilli have developed the ability to hydrolyze proteins presentin their environment.
Cyril Raveschot, Cyril Raveschot, Benoit Cudennec, François Coutte, Christophe Flahaut,Marc Fremont, Djamel Drider, Pascal Dhulster 2018, 'Production of Bioactive Peptides by Lactobacillus Species: From Gene to Application',Frontiers in Microbiologyhttps://www.frontiersin.org/article/10.3389/fmicb.2018.02354/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)