The pathogenic mechanisms of these cardiovascular changes are multifactorial and include neurohumoral and vascular dysregulations.
Al-Hamoudi Waleed 2010, 'Cardiovascular changes in cirrhosis: Pathogenesis and clinical implications', The Saudi Journal of Gastroenterologyhttp://www.saudijgastro.com/article.asp?issn=1319-3767;year=2010;volume=16;issue=3;spage=145;epage=153;aulast=Al-Hamoudi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hypoxia elicits a neurohumoral and haemodynamic response that may provoke increased capillary pressure and oedema.
F.J. Carod-Artal 2014, 'High-altitude headache and acute mountain sickness', Neurología (English Edition)http://www.sciencedirect.com/science/article/pii/S2173580814001321. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pathological cardiac hypertrophy used to be elucidated by biomechanical, stretch-sensitive or neurohumoral mechanisms.
Rongrong Sun, Baoling Zhu, Kai Xiong, Yan Sun, Dandan Shi, Li Chen, Youyi Zhang, ZijianLi, Lixiang Xue 2017, 'Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiachypertrophy', PLOS ONE10.1371/journal.pone.0182668. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The renal function, and metabolic and neurohumoral parameters, did not change significantly.
Aurelio Negro, Antonio Manari, Rosaria Santi, Chiara Grasselli, Simona Davoli, GianlucaPignatelli, Mila Menozzi, Franco Perazzoli 2013, 'Endovascular radiofrequency renal denervation in resistant hypertension: a singlecenter experience', Italian Journal of Medicinehttp://www.italjmed.org/index.php/ijm/article/view/174. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antagonists of mineralocorticoid receptors, along with angiotensin-converting enzyme inhibitors and beta-blockers, are neurohumoral modulators.
O. M. Drapkina, D. U. Akasheva 2017, 'PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY', Racionalʹnaâ Farmakoterapiâ v Kardiologiihttps://www.rpcardio.com/jour/article/view/1508. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Then we describe the neurohumoral mechanisms controlling airway tone.
Michele Baroffio, Giovanni Barisione, Emanuele Crimi, Vito Brusasco 2009, 'Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: anoverview', Therapeutic Advances in Respiratory Diseasehttps://doi.org/10.1177/1753465809343595. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The biological effects of acupuncture include the regulation of a variety of neurohumoral factors and growth control factors.
Charles Shang 2009, 'Prospective Tests on Biological Models of Acupuncture', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1093/ecam/nem122. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Activation of neurohumoral systems aims to support the adaptation processes and homeostasis in heart failure syndrome but often causes harm.
Katerenchuk O. 2013, 'Depression аnd Cardiovascular Diseases: Cause, Consequence оr Comorbidity', Львівський клінічний вісникhttp://lkv.biz/depression-and-cardiovascular-diseases-cause-consequence-or-comorbidity/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
During experimental work it was crucial to develop appropriate animal models, where the neurohumoral mechanism was similar to humans.
Bogi Eszter, Belovicova Kristína, Csatlosova Kristína, Dubovicky Michal 2017, 'Animal models of maternal depression for monitoring neurodevelopmental changes occurringin dams and offspring', Interdisciplinary Toxicologyhttp://www.degruyter.com/view/j/intox.2017.10.issue-1/intox-2017-0005/intox-2017-0005.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)