a toxic antibiotic that inhibits protein synthesis, used as a fungicide in agriculture
cycloheximide in American English
(ˌsaiklouˈheksəˌmaid, -mɪd)
noun
Pharmacology
an antibiotic substance, C15H23NO4, isolated from the bacterium Streptomyces griseus, used experimentally to block protein synthesis
Word origin
[1945–50; cyclohex(ane) + imide]This word is first recorded in the period 1945–50. Other words that entered Englishat around the same time include: beeper, fail-safe, poison pill, regression analysis, synchronized swimming
Examples of 'cycloheximide' in a sentence
cycloheximide
Roles for transactivation were investigated using the protein synthesis inhibitor, cycloheximide.
Elizabeth M King, Joanna E Chivers, Christopher F Rider, Anne Minnich, Mark A Giembycz,Robert Newton 2013, 'Glucocorticoid repression of inflammatory gene expression shows differential responsivenessby transactivation- and transrepression-dependent mechanisms.', PLoS ONEhttp://europepmc.org/articles/PMC3545719?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
By contrast, stress-induced ribosome accumulation on the 5′ side of coding sequences was cycloheximide-dependent.
Caia D. S. Duncan, Juan Mata 2017, 'Effects of cycloheximide on the interpretation of ribosome profiling experiments inSchizosaccharomyces pombe', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-10650-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Increase in peroxidase activity was evidently inhibited by cycloheximide.
Nityananda Chakraborty, Balen Nandi 2015, 'Enzyme activity in banana fruits rotted by Botryodiplodia theobromae Pat.', Acta Agrobotanicahttps://pbsociety.org.pl/journals/index.php/aa/article/view/5946. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To test for endogenous actions following biosynthesis, we increased intracellular amino acid levels with cycloheximide.
Elizabeth A Gozal, Brannan E O'Neill, Michael A Sawchuk, Hong eZhu, Mallika eHalder,Ching-Chieh eChou, Shawn eHochman 2014, 'Anatomical and functional evidence for trace amines as unique modulators of locomotorfunction in the mammalian spinal cord', Frontiers in Neural Circuitshttp://journal.frontiersin.org/Journal/10.3389/fncir.2014.00134/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cycloheximide given after the reactivation treatment produced a strong impairmentthat persisted over test sessions.
Ali Rashidy-Pour, Saeed Nikzad, Roghyeh Pakdel, Abbas Ali Vafaei 2011, 'Effects of Mineralocorticoid Receptors Blockade on FearMemory Reconsolidation in Rats',Basic and Clinical Neurosciencehttp://bcn.tums.ac.ir/browse.php?a_code=A-10-1-77&slc_lang=en&sid=1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The membrane deformations were absent after cycloheximide treatment.
Anu B Machettira, Lucia E Groß, Bodo eTillmann, Benjamin LM Weis, Giesela eEnglich,Maik S Sommer, Martina eKöniger, Enrico eSchleiff 2012, 'Protein induced modulation of chloroplast membrane morphology', Frontiers in Plant Sciencehttp://journal.frontiersin.org/Journal/10.3389/fpls.2011.00118/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The up-regulation of their contractility was blunted by cycloheximide treatment, a translational inhibitor.
Vikman Petter, Nilsson Elisabeth, Xu Cang-Bao, Granström Bengt W, Edvinsson Lars 2006, 'Smoking particles enhance endothelin A and endothelin B receptor-mediated contractionsby enhancing translation in rat bronchi', BMC Pulmonary Medicinehttp://www.biomedcentral.com/1471-2466/6/6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both neurotensin-induced excitation and dopamine desensitization were inhibited in the presence of cycloheximide.
Sudarat eNimitvilai, Devinder S. Arora, Maureen A. McElvain, Mark S. Brodie 2013, 'Suppression of Gq function using intrapipette delivery of shRNA during extracellularrecording in the ventral tegmental area', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fncel.2013.00007/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Imipenem and cycloheximide were the best antibiotics for purification of cultures.
Mostafa Noroozi, Mohammad Ali Amozegar, Rezvan Rahimi, Seyed Abolhassan ShahzadehFazeli, Gholamreza Bakhshi Khaniki 2017, 'The isolation and preliminary characterization of native cyanobacterial and microalgalstrains from lagoons contaminated with petroleum oil in Khark Island', Biological Journal of Microorganismhttp://bjm.ui.ac.ir/article_21144_d6e00cc455157835a97f6cd5655e8c16.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The following inhibitors were used: α-amanitin, cordycepin, cycloheximide and 5-fluorouracil.
Stanisław Weidner, Włodzimierz Makowski, Andrzej Rejowski 2014, 'The use of transcription inhibitors in the study of the mechanism of abscisic acidaction in germinating triticale caryopses', Acta Societatis Botanicorum Poloniaehttps://pbsociety.org.pl/journals/index.php/asbp/article/view/3015. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)