calcitoninn.

Brit.

/ˌkalsᵻˈtəʊnɪn/, U.S.

/ˌkælsəˈtoʊnən/

Origin: Formed within English, by derivation. Etymons: calcium n., tone n., -in suffix¹.

Etymology: < calci- (in calcium n.) + tone n. + -in suffix¹ (see quot. 1962 at main sense).

Physiology and Biology.

A polypeptide hormone secreted by the parafollicular cells of the thyroid in mammals and by the ultimobranchial body in other vertebrates, which lowers the levels of calcium and phosphate in the blood by promoting the absorption and retention of calcium in bone, and by increasing the rate of excretion of calcium and phosphate in urine.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > hormone > [noun] > other hormones

thyro-iodine1896

parathormone1925

parathyroid hormone1925

oestrin1926

oestrogen1927

relaxin1930

theelin1930

prolan1931

galactin1932

inhibin1932

prolactin1932

oestriol1933

oestrone1933

oestradiol1934

adrenocorticotrophin1943

pancreozymin1943

ADH1945

adrenocorticotropin1945

cortisone1949

mineralocorticoid1950

electrocortin1953

aldosterone1954

angiotensin1958

melatonin1958

calcitonin1961

zeranol1971

amylin1988

adiponectin1999

adipokine2001

1961 D. H. Copp et al. in Proc. Canad. Federation Biol. Sci. 4 17/2 The name ‘calcitonin’ is suggested for this humoral substance to distinguish it from the regular parathyroid hormone.

1962 D. H. Copp et al. in Endocrinology 70 648/2 Since this new hormone is involved in the regulation of the normal ‘tone’ of calcium in the body fluids, we have suggested that it be named ‘calcitonin’.

1967 Canad. Med. Assoc. Jrnl. 97 941/1 Since the so-called parafollicular or light cells of the thyroid gland..are probably derived from ultimobranchial rather than thyroid tissue, the original name calcitonin seems preferable to thyrocalcitonin.

1980 Proc. National Acad. Sci. U.S.A. 77 4444/1 This clonal cDNA was used as a probe to assay the expression of the calcitonin gene.

1981 R. N. Hardy Endocrine Physiol. viii. 90 Calcitonin serves to lower Ca²⁺ concentration in blood by increasing bone calcium stores.

1991 D. J. Weatherall New Genetics & Clin. Pract. (ed. 3) xi. 336 The calcitonin gene generates two messenger RNAs, one encoding the precursor of a novel neuropeptide, the other the precursor of the hormone calcitonin; the neuropeptide predominates in the nervous system.

1996 Fibromyalgia Times Fall 7/2 There are now alternatives for the treatment of osteoporosis. These include a nasal spray—calcitonin (Miacalcin) and a tablet—alendronate (Fosamax).

Compounds

calcitonin gene-related peptide n. a neuropeptide produced esp. in the hypothalamus, which acts as a neuromodulator, and is a potent vasodilator and hypotensive agent.

ΚΠ

1982 Nature 15 July 240 Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP).

1990 Sci. News Apr. 244/2 Researchers have now found that an experimental drug—calcitonin-gene-related peptide—temporarily reversed symptoms caused by reduced blood flow to the brain.

2001 Jrnl. Musculoskeletal & Neuronal Interactions 2 137 The innervation of callus reveals an extensive distribution of sensory fibers containing a calcitonin gene-related peptide, a neuropeptide with potent vasodilatory actions.

This is a new entry (OED Third Edition, September 2003; most recently modified version published online December 2021).

单词	calcitonin
释义	calcitoninn. Brit. /ˌkalsᵻˈtəʊnɪn/, U.S. /ˌkælsəˈtoʊnən/ Origin: Formed within English, by derivation. Etymons: calcium n., tone n., -in suffix¹. Etymology: < calci- (in calcium n.) + tone n. + -in suffix¹ (see quot. 1962 at main sense). Physiology and Biology. A polypeptide hormone secreted by the parafollicular cells of the thyroid in mammals and by the ultimobranchial body in other vertebrates, which lowers the levels of calcium and phosphate in the blood by promoting the absorption and retention of calcium in bone, and by increasing the rate of excretion of calcium and phosphate in urine. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > hormone > [noun] > other hormones thyro-iodine1896 parathormone1925 parathyroid hormone1925 oestrin1926 oestrogen1927 relaxin1930 theelin1930 prolan1931 galactin1932 inhibin1932 prolactin1932 oestriol1933 oestrone1933 oestradiol1934 adrenocorticotrophin1943 pancreozymin1943 ADH1945 adrenocorticotropin1945 cortisone1949 mineralocorticoid1950 electrocortin1953 aldosterone1954 angiotensin1958 melatonin1958 calcitonin1961 zeranol1971 amylin1988 adiponectin1999 adipokine2001 1961 D. H. Copp et al. in Proc. Canad. Federation Biol. Sci. 4 17/2 The name ‘calcitonin’ is suggested for this humoral substance to distinguish it from the regular parathyroid hormone. 1962 D. H. Copp et al. in Endocrinology 70 648/2 Since this new hormone is involved in the regulation of the normal ‘tone’ of calcium in the body fluids, we have suggested that it be named ‘calcitonin’. 1967 Canad. Med. Assoc. Jrnl. 97 941/1 Since the so-called parafollicular or light cells of the thyroid gland..are probably derived from ultimobranchial rather than thyroid tissue, the original name calcitonin seems preferable to thyrocalcitonin. 1980 Proc. National Acad. Sci. U.S.A. 77 4444/1 This clonal cDNA was used as a probe to assay the expression of the calcitonin gene. 1981 R. N. Hardy Endocrine Physiol. viii. 90 Calcitonin serves to lower Ca²⁺ concentration in blood by increasing bone calcium stores. 1991 D. J. Weatherall New Genetics & Clin. Pract. (ed. 3) xi. 336 The calcitonin gene generates two messenger RNAs, one encoding the precursor of a novel neuropeptide, the other the precursor of the hormone calcitonin; the neuropeptide predominates in the nervous system. 1996 Fibromyalgia Times Fall 7/2 There are now alternatives for the treatment of osteoporosis. These include a nasal spray—calcitonin (Miacalcin) and a tablet—alendronate (Fosamax). Compounds calcitonin gene-related peptide n. a neuropeptide produced esp. in the hypothalamus, which acts as a neuromodulator, and is a potent vasodilator and hypotensive agent. ΚΠ 1982 Nature 15 July 240 Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). 1990 Sci. News Apr. 244/2 Researchers have now found that an experimental drug—calcitonin-gene-related peptide—temporarily reversed symptoms caused by reduced blood flow to the brain. 2001 Jrnl. Musculoskeletal & Neuronal Interactions 2 137 The innervation of callus reveals an extensive distribution of sensory fibers containing a calcitonin gene-related peptide, a neuropeptide with potent vasodilatory actions. This is a new entry (OED Third Edition, September 2003; most recently modified version published online December 2021). < n.1961
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