transaminationn.
/ˌtrɑːnzamɪˈneɪʃən//ˌtranzamɪˈneɪʃən//ˌtrɑːnsamɪˈneɪʃən//ˌtransamɪˈneɪʃən/ Biochemistry.
The transfer of an amino group from one organic molecule to another, esp. from an amino-acid to a keto-acid.
ΚΠ
1939 Nature 8 Apr. 609/1 The reversible transfer of amino groups between aminodicarboxylic acids and α-keto~acids, or ‘trans-amination’..is of almost universal occurrence in biological objects.
1946 Nature 12 Oct. 515/2 Not until it reaches the root cells does the transformation of aspartic acid take place (through deamination, trans~amination, etc.).
1959 A. White et al. Princ. Biochem. (ed. 2) xx. 514 In addition to transamination reactions involving l-α-amino acids, transamination of..aldehydes..has also been observed.
1982 T. I. Diamondstone in T. M. Devlin Textbk. Biochem. xi. 546 Virtually every protein amino acid undergoes transamination at some point in its metabolic breakdown.
Derivatives
Hence (as back-formations)
transˈaminate v. (intransitive) to undergo transamination; transitive, to deprive of an amino group; to change by transamination.
ΚΠ
1955 A. Meister in McElroy & Glass Amino Acid Metabolism i. 14 l-Alloisoleucine and its keto analogue..transaminate at somewhat slower rates than l-isoleucine.
1970 R. W. McGilvery Biochemistry xvii. 355 Any other amino acid that will transaminate with α-ketoglutarate may be deaminated in the same way.
transˈaminated adj.
ΚΠ
1940 Jrnl. Biol. Chem. 136 573 Braunstein reports that these amino acids are transaminated to the extent of 17 to 21 per cent.
1972 Nature 8 Sept. 101/2 The group..included amino-acids..that are not transaminated or oxidized in myocardium and those..that can be transaminated and used for energy production.
1974 I. B. R. Bowman in K. Elliott et al. Trypanosomiasis & Leishmaniasis 268 It is likely that glutamate is trans~aminated to α-oxoglutarate.
transˈaminating adj. and n.
ΚΠ
1940 Ann. Rev. Biochem. 9 284 The experiments..disclose the possible operation of the transaminating enzymes within the animal body.
1959 A. White et al. Princ. Biochem. (ed. 2) xx. 517 The discovery of the transaminating mechanism.
This entry has not yet been fully updated (first published 1986; most recently modified version published online September 2018).
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