Tofraniln.
/ˈtɒfrənɪl/ Pharmacology.
A proprietary name for the drug imipramine.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs
Marsilid1952
iproniazid1953
levallorphan1953
imipramine1958
Tofranil1958
isocarboxazid1959
Marplan1959
Nardil1959
nialamide1959
Niamid1959
phenelzine1959
tranylcypromine1959
Parnate1960
amitriptyline1961
monoamine oxidase inhibitor1962
nortriptyline1962
protriptyline1963
MAOI1965
maprotiline1970
mianserin1970
amoxapine1971
fluoxetine1975
paroxetine1977
Prozac1985
Seroxat1985
1958 Trade Marks Jrnl. 4 June 564/2 Tofranil... Pharmaceutical preparations for human and veterinary use... J. R. Geigy..Basle, Switzerland.
1958 Official Gaz. (U.S. Patent Office) 16 Sept. tm91/2 Geigy Chemical Corporation, Ardsley, N.Y...Tofranil for antidepressants.
1963 Lancet 23 Mar. 638/2 The administration to pregnant rabbits of imipramine (‘Tofranil’) led to the development of fœtal abnormalities.
1965 J. Pollitt Depression & its Treatm. iv. 58 Imipramine is effective mainly in Type S classical (retarded) depressions, and in depressed patients of middle age and over. It is less valuable in atypical depression, and in sensitive or hysterical personalities the ordinary mild side effects may cause bitter complaint.
1979 Daily Tel. 27 Nov. 12/7 Prescriptions for the brand leaders Tofranil and Tryptizol accounted for an estimated £5 million.
This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).
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n.1958