α. Middle English tethanus, Middle English thetanus, Middle English– tetanus, 1500s thetanos, 1600s–1700s tetanon, 1600s–1700s tetanos, 1700s tetanas.
β. Middle English 1600s tetan, Middle English–1600s tetane.
单词 | tetanus |
释义 | tetanusn.α. Middle English tethanus, Middle English thetanus, Middle English– tetanus, 1500s thetanos, 1600s–1700s tetanon, 1600s–1700s tetanos, 1700s tetanas. β. Middle English 1600s tetan, Middle English–1600s tetane. 1. Medicine. a. A disease of humans and animals characterized by persistent contraction of some or most of the voluntary muscles of the body, with superimposed severe muscle spasms, often resulting in death by asphyxiation if untreated. Also (in later use with distinguishing word): any of various other diseases or disorders characterized by muscle spasms or by contracture of a part of the body (now historical and rare). In early use sometimes used specifically (following ancient and Hellenistic Greek usage) for a kind of generalized muscle spasm in which the body is held in a rigidly straight position, in contrast to emprosthotonos n. and opisthotonos n., in which the body is curved forwards or backwards, respectively.Tetanus is caused by a neurotoxin (tetanospasmin) produced by the anaerobic bacterium Clostridium tetani, the spores of which enter the body through dirty wounds (esp. puncture wounds and, in newborn infants, the stump of the umbilical cord). The initial sign of tetanus is often persistent contraction of the jaw muscles (see lockjaw n. 1 and trismus n.).Tetanus can be treated successfully with antitoxin, and prevented by immunization with a toxoid. ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > disorders affecting muscles > [noun] > spasm or cramp > tetanus tetanusa1398 shotec1440 opisthotonos1582 emprosthotonos1585 jaw-fallen1631 tetanism1681 trismus1684 locked jaw1754 lockjaw1768 pleurothotonos1783 seven day disease1789 orthotonos1869 pleurotonus1899 a1398 J. Trevisa tr. Bartholomaeus Anglicus De Proprietatibus Rerum (BL Add. 27944) (1975) I. vii. xiii. 358 This crampe hath þre manere of kyndes..þe þridde hatte tethanus, and is whenne þe furþir and hindir [sinouis] schrinken. ?a1450 tr. Macer Herbal (Stockh.) (1949) 179 Þe disease and contraccon þat is clepid tetanus. 1559 P. Morwyng tr. C. Gesner Treasure of Euonymus 364 In the disease of the necke called Tetanus, whiche is the stifnes of the sinnewes (saith Celsus) it is necessarie to haue a moyste and warme fomentacion. 1576 T. Newton tr. L. Lemnie Touchstone of Complexions i. ii. f. 15v If the wayes and passages whereby this spirite oughte to goe and haue passage, bee stopped & affected, the power of mouing and feeling is taken away, as we euidently note and see to happen in the Apoplexie, Palsey, Tetanus, and many diseases moe. 1651 D. Border Πολυϕαρμακος και Χυμιστης lvi. 28 A Child had her neck drawn awry, with a kind of convulsion or cramp called Tetanus, and was thus cured. 1678 J. Browne Compl. Disc. Wounds xi. 61 If by reason of a Wound Tetanos or Distention does happen, the Patient's Mandibles are conglutinated, he cannot open his Mouth, his Eyes are filled with tears and contracted, his posteriour Parts are convelled, and his Body is bent backwards. 1725 E. Strother Ess. Sickness & Health (ed. 2) 124 A Cramp, call'd Tetanus, is a permanent and lasting Contraction of any Part. 1789 M. Underwood Treat. Dis. Children (rev. ed.) I. 191 The Tetanus, or Locked-Jaw of infants, is an equally fatal complaint. 1824 G. P. Dawson Nosol. Pract. Physic 220 Tetanus is divided into acute and chronic, according to its mildness or severity; into idiopathic; and traumatic, when from a wound. 1830 J. Baxter Libr. Agric. & Hort. Knowl. 280 Tetanus is one of the most formidable and fatal diseases to which the horse is liable. 1880 Physicians & Surgeons' Investigator 1 75 The difference between the symptoms and anatomical characters of true and drug tetanus is well marked. 1913 W. A. White & S. E. Jelliffe Mod. Treatm. Nerv. & Mental Dis. II. 194 Known in the literature by various names, tetanilla, idiopathic muscle spasms, intermittent tetanus, etc., the disease described below has been known as tetany since Frankl-Hochwart's classical and exhaustive treatise in 1887. 1953 R. W. Fairbrother Text-bk. Bacteriol. (ed. 7) ix. 108 These toxins..are now employed extensively both for prophylaxis against diphtheria and tetanus and for the preparation of antitoxic sera in horses. 1994 N.Y. Times 11 Jan. c7/2 The vaccine for whooping cough, also known as pertussis, is usually given in combination with immunizations against diphtheria and tetanus, as DPT shots. 2010 Daily Tel. 5 Jan. 2 (headline) A medical mission: Afghan boy with tetanus wins the hearts of British life savers. b. As a count noun: an instance, case, or type of tetanus; (esp. in early use) a muscle spasm or cramp. Now rare. ΚΠ α. β. a1400 tr. Lanfranc Sci. Cirurgie (Ashm.) (1894) 104 If þat a man haue a crampe or ellis a tetane þat is a sijknes þat halt þe membre lich streit on boþe sidis.c1475 ( Surg. Treat. in MS Wellcome 564 f. 97 That if a man hadde a crampe or ellis a tetan, if þe feuere come þeron, it schulde dissoluen þe sijknesse.?1608 J. Donne Lett. (1651) 31 For it [sc. a sicknesse] hath so much of a continuall Cramp, that it wrests the sinews, so much of a Tetane, that it withdraws and puls the mouth.1610 S. H. tr. Hippocrates Whole Aphorismes 86 But the vse of colde water bringeth convulsions, the crampes called Tetani, blackness & cold shakings vsuall in some feuers. 1661 T. Whitaker Elenchus of Opinions Cure of Small Pox 82 Fourthly, a Tetanus is cured by pouring water upon the head.., but a return is from a cold cause, and cured by a cold remedy. 1700 C. Leigh Nat. Hist. Lancs. 73 The case was what is generally call'd a Timpany; which..arose neither from a Tetanus of the Stomach, nor as the Ancients wou'd have it, from the flatness, or vapours of the Abdomen. 1753 N. Torriano Non-naturals 66 In Epilepsies and Distractions, swooning Fits, Tetanus's and Catalepsis. 1763 J. Pringle Let. in B. Franklin Papers (1966) X. 270 The distemper was a tetanas viz. an obstinate cramp of the muscles of the neck. 1794 Analyt. Rev. July 256 Dr. Rush was at first unable to determine whether the case were a tetanus, or the sore throat, then prevalent in the city and vicinity. 1906 Trans. Maine Med. Assoc. 15 316 The old etiological grouping recognized four varieties, a traumatic, a rheumatic, an idiopathic and a toxic tetanus. 1919 Eng. Jrnl. 8 20 The nature of stuttering seems to be a cramp or tetanus of some respirational muscle or organ. 2. Physiology. Sustained contraction of a muscle produced by rapidly repeated electrical or chemical stimulation; an instance of this. ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > disorders affecting muscles > [noun] > prolonged contraction rigidity1708 tetanus1847 1847 Philos. Trans. (Royal Soc.) 137 236 If..the nerve be divided rapidly at the precise point where it enters the muscle, the limb is thrown into contraction without its remaining in a state of tetanus. 1884 J. M. Robertson Elements Physiol. Physics viii. 87 Stimulate till tetanus affects the muscle, then electrotonise. 1940 G. S. Carter Gen. Zool. Invertebr. xviii. 364 The contraction during a tetanus is stronger than the maximum contraction of a twitch. 1996 S. L. Lehman et al. in S. A. Berger et al. Introd. Bioengin. x. 407/1 As the stimulus frequency increases, twitches begin to sum, relaxation from one stimulus not being complete before onset of the next. Above a rate termed ‘fusion frequency’, a smooth maximal contraction called ‘tetanus’ is obtained. Compounds C1. a. General attributive, as tetanus antitoxin, tetanus bacillus, etc. ΚΠ 1837 Amer. Jrnl. Med. Sci. 20 95 But since anatomists have learned to place less reliance upon mere redness and turgescence, as indications of inflammation during life, the profession have become less and less satisfied, as to the constant presence of morbid changes in the spines of tetanus patients. 1896 T. C. Allbutt et al. Syst. Med. I. 237 The diphtheria and tetanus antitoxins act directly on the toxins. 1908 Carnegie Trust Universities Scotl.: Interim Rep. 25 The action of tetanus toxin on the central nervous system. 1953 R. W. Fairbrother Text-bk. Bacteriol. (ed. 7) xxix. 359 The tetanus bacillus produces two distinct toxic substances—(1) tetano-spasmin and (2) tetanolysin. 2006 Science 28 Apr. 541/1 Tetanus toxin is transported along the axons into the spinal cord where it crosses the synaptic cleft and inhibits the nerve terminals of glycinergic interneurons. b. attributive, designating an injection administered to immunize against tetanus, as tetanus injection, tetanus jab, tetanus shot, etc. ΚΠ 1895 Med. Rec. 12 Jan. 59/1 This is not exactly analogous to the tetanus injections. 1934 Chicago Tribune 12 Nov. 1/7 (heading) Firemen get tetanus shots. 1964 Los Angeles Times 16 Aug. (Calendar section) 6/3 The handler and I were whisked into town for tetanus jabs. 1996 Which? Mar. 16/1 He also received a tetanus jab and a prescription for antibiotics. 2003 Sunday Mail (Brisbane) 24 Aug. (Body & Soul section) 10/4 Regular tetanus boosters for life are recommended, often given as ADT (Adult Diphtheria Tetanus). C2. Instrumental, as tetanus-afflicted, tetanus-infected, etc. Also figurative (chiefly humorous). ΚΠ 1857 Ld. Dufferin Lett. from High Latitudes vii. 92 Our dinner went off merrily; the tetanus-afflicted salmon proved excellent. 1910 Brit. Med. Jrnl. 12 Nov. 1501/1 We know, for example, that anthrax and tetanus infected soils are almost permanently dangerous. 1914 Mining & Engin. World 1 Aug. 207/1 Mining and Engineering World feels almost like congratulating itself for having, after many years, succeeded in prying open the tetanus-afflicted jaw of the Journal. 1984 Neurosci. Lett. 51 232 Virtually no grains were found over motoneurons or interneurons of the tetanus-affected side. 2007 Vaccine 25 7018/1 U.S. biologic safety regulation efforts commenced in 1902..following the deaths of 13 children in 1901 attributed to tetanus infections contracted via administration of diphtheria antitoxin generated by a tetanus-infected horse. Derivatives ˈtetanus-like adj. ΚΠ 1854 Lancet 7 Jan. 21/1 The spasmodic tetanus-like rigidity and distortion of the limbs of new-born infants, which the author has traced to asphyxia neonatorum, and mechanical injury to the fœtus immediately before or during parturition. 1930 Science 6 June 586/2 The only indication of a possible drug action encountered was a tetanus-like hyperexcitability of frogs. 2003 Jrnl. Clin. Virol. 26 270/1 In boars and sows, acute febrile illness with labored respiration, increased salivation, and nasal discharge accompanied neurological signs such as..tetanus-like spasm and seizures. This entry has been updated (OED Third Edition, December 2012; most recently modified version published online June 2022). < |
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