synthetasen.

1947 Cohen & McGilvery in Jrnl. Biol. Chem. 171 132 We wish to suggest the term ‘synthetase’ for those enzymes creating a new molecule by the elimination of water between two substrate molecules, excluding the formation of phosphote esters and anhydrides.

1961 Rep. Comm. Enzymes Internat. Union Biochem. vi. 39 Enzymes catalysing the linking together of two molecules, coupled with the breaking of a pyrophosphate link in ATP, etc., will be known as ligases (pronounced with a short ‘i’ in English). These enzymes have hitherto been known as synthetases... A new systematic name was necessary.

1961 Rep. Commission on Enzymes v. 37 Enzymes removing groups from substrates non-hydrolytically, leaving double bonds (or adding groups to double bonds) will be called ‘lyases’... ‘Synthetase’ will not be used for any enzymes in this class; where it has been customary, ‘synthase’ will be used instead.

1972 Nature 15 Dec. 377/1 Aspirin and aspirin-like drugs inhibit..the synthetase which synthesizes prostaglandins from the unsaturated fatty acid, arachidonic acid.

1979 Sci. Amer. May 78/2 Interferon also induces the manufacture of a second enzyme, a synthetase that catalyzes the polymerization of adenine nucleotides into a long chain of adenine units called 2,5-oligoadenylic acid.