| 单词 | substitution mutation | 
| 释义 | > as lemmassubstitution mutation  10.  Genetics. The replacement of one nucleotide or amino acid for another in a DNA or protein molecule; an instance of this. Frequently attributive, esp. in  substitution mutation. Cf. point mutation n. at point n.1 Compounds 2. ΚΠ 1957    V. M. Ingram in  Nature 17 Aug. 328/1  				A substitution in the nucleic acids leads to a substitution in the poly-peptide. 1980    Proc. National Acad. Sci. U.S.A. 77 6491/1  				Viruses with substitution mutations in one of the T antigen binding sites were shown to have reduced rates of DNA synthesis at low temperatures. 1990    Science 31 Aug. 1025/1  				This single amino acid substitution changes the hydropathy profile of the flanking peptide segment. 2004    J. Adds et al.  Genetics, Evol. & Biodiversity 		(rev. ed.)	 vi. 93  				Sickle-cell anaemia arises because of a substitution mutation in a single codon, which specifies valine instead of glutamic acid. < as lemmas  | 
	
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