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单词 bleomycin
释义

bleomycinn.

/bliːəʊˈmʌɪsɪn/
Etymology: Arbitrary alteration of earlier phleomycin , name of a related antibiotic, < phleo- , of unknown origin + -mycin suffix.
Pharmacology.
An antineoplastic drug consisting of a glycopeptide or mixture of glycopeptides from the bacterium Streptomyces verticillus.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for tumour
platinum blue1908
nitrogen mustard1943
mustard1945
piperoxan1950
melphalan1960
procarbazine1965
bleomycin1966
1966 H. Umezawa in Antimicrobial Agents & Chemotherapy 1965 1080/2 An antibiotic complex produced by another strain of Streptomyces was more stable than phleomycin at acid and alkaline pH, but chelated with copper... This complex of the phleomycin group was named bleomycin.
1970 Jrnl. Antibiotics 23 473 The bleomycins, water-soluble basic glycopeptide antibiotics, produced by Streptomyces verticillus, exhibit antitumour and antibacterial activity... There are more than 13 bleomycins.
1979 Sci. Amer. Aug. 33/3 The antitumor drug bleomycin..does its therapeutic work by damaging the DNA of tumor cells.
1981 M. C. Gerald Pharmacol. (ed. 2) xxx. 586 With the exception of bleomycin, all other antitumor antibiotics..cause bone marrow depression.
1984 Brit. National Formulary (Brit. Med. Assoc.) viii. 269/1 Bleomycin is used to treat the lymphomas, certain solid tumours and..malignant effusions.
This entry has not yet been fully updated (first published 1993; most recently modified version published online June 2018).
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n.1966
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