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单词 raloxifene
释义

raloxifenen.

Brit. /rəˈlɒksᵻfiːn/, /rəˈlɒksᵻfɛn/, U.S. /ræˈlɑksəˌfin/, /ræˈlɑksəˌfɛn/
Forms: 1900s– raloxifen, 1900s– raloxifene.
Origin: Formed within English, by compounding. Etymons: English ral- , oxy- comb. form2, pheno- comb. form.
Etymology: < ral- (of unknown origin) + oxi- (representing oxy- comb. form2) + -fene (representing pheno- comb. form; compare phene n.). Compare earlier tamoxifen n.
Pharmacology.
A drug that is a selective oestrogen receptor modulator (stimulating oestrogen receptors in bone and blocking those in the breast and uterus), used chiefly in the treatment of osteoporosis.Chemical name: [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl] [4-(2-piperidinoethoxy)phenyl]methanone, C28H27NO4S.
ΚΠ
1985 WHO Chron. 39 iv. Suppl. 16 Raloxifene... 6-hydroxy-2-(p-hydroxyphenyl)benzo[b]thien-3-yl p-(2-piperidinoethoxy)-phenyl ketone.
1993 Prostate 23 245 The benzothiophene anti-estrogen, raloxifene...has selective estrogen pharmacological antagonist activity in female rats.
1998 Syracuse (N.Y.) Herald-Jrnl. 22 Oct. a4/3 The new drug will compare tamoxifen with the osteoporosis drug raloxifen to see if raloxifen will prevent breast cancer with fewer side effects.
2005 Elevate New Year 83/1 Dr. Lawrence and her team..at the University of Ottawa have determined that the anti-estrogen drugs tamoxifen and raloxifene can be used to treat persistent pubertal gynecomastia.
This is a new entry (OED Third Edition, June 2008; most recently modified version published online March 2022).
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n.1985
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