benzodiazepinen.

/bɛnzəʊdʌɪˈazəpiːn/

Etymology: < benzo- comb. form + di- comb. form + azo- comb. form + -epine, suffix denoting a seven-membered ring containing nitrogen, ( < -ep- (in hepta- comb. form) + -ine suffix⁵).

Chemistry and Pharmacology.

Any compound whose molecule contains a benzene ring fused to a seven-membered ring containing two nitrogen atoms; spec. any of a group of such compounds used as hypnotics and anxiolytics and sometimes causing psychological dependence.

ΘΚΠ

the world > matter > chemistry > organic chemistry > hydrocarbons > [noun] > benzene derivatives > other benzene derivatives

iodoxybenzene1865

retene1866

trimethylbenzene1868

quinol1871

paradichlorobenzene1876

coumarone1883

thiophene1883

antipyrin1884

thiotoluene1885

thioxylene1885

phthalaldehyde1886

trimesic acid1889

iodosobenzene1892

benzodiazepine1934

the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > hypnotic > specific drugs

codeine1833

codeia1834

chloral1838

paraldehyde1857

hypnone1886

chloralamide1889

sulphonal1889

uralium1889

ural1891

thymacetin1892

chloralose1893

chloretone1899

hedonal1900

veronal1903

Medinal1908

barbitone1914

barbital1919

Sedormid1928

benzodiazepine1934

hexobarbital1941

hexobarbitone1941

glutethimide1955

Placidyl1955

Mogadon1956

chlordiazepoxide1960

nitrazepam1965

flurazepam1968

medazepam1968

lorazepam1969

Rohypnol1971

flunitrazepam1973

triazolam1973

methapyrilene1974

Halcion1975

1934 Chem. Abstr. 28 8031 C₆-C₅N₂ Benzodiazepine.

1960 Jrnl. Pharmacol. & Exper. Therapeutics 129 163/1 Methaminodiazepoxide HCl (Librium HCl) is a psychosedative drug of a new chemical type... Methaminodiazepoxide..is 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride.

1961 Current Therapeutic Res. III. 424 Valium is a new psychotherapeutic agent in the 1,4-benzodiazepine class.

1968 Chem. Rev. 68 748/1 The 1,4-benzodiazepines form the most extensively explored group in this series, largely owing to the discovery of their interesting biological activity, which has led to the introduction of four drugs... The 1,5-benzodiazepines have been thoroughly studied during a period of several decades, largely because of their relatively easy synthesis.

1976 Lancet 30 Oct. 936/2 Barbiturates or benzodiazepines were given to ensure sleep during the preceding night.

1984 A. Smith Mind iv. xiv. 265 Over sixty million prescriptions for benzodiazepines are filled in annually.

This entry has not yet been fully updated (first published 1972; most recently modified version published online March 2020).

单词	benzodiazepine
释义	benzodiazepinen. /bɛnzəʊdʌɪˈazəpiːn/ Etymology: < benzo- comb. form + di- comb. form + azo- comb. form + -epine, suffix denoting a seven-membered ring containing nitrogen, ( < -ep- (in hepta- comb. form) + -ine suffix⁵). Chemistry and Pharmacology. Any compound whose molecule contains a benzene ring fused to a seven-membered ring containing two nitrogen atoms; spec. any of a group of such compounds used as hypnotics and anxiolytics and sometimes causing psychological dependence. ΘΚΠ the world > matter > chemistry > organic chemistry > hydrocarbons > [noun] > benzene derivatives > other benzene derivatives iodoxybenzene1865 retene1866 trimethylbenzene1868 quinol1871 paradichlorobenzene1876 coumarone1883 thiophene1883 antipyrin1884 thiotoluene1885 thioxylene1885 phthalaldehyde1886 trimesic acid1889 iodosobenzene1892 benzodiazepine1934 the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > hypnotic > specific drugs codeine1833 codeia1834 chloral1838 paraldehyde1857 hypnone1886 chloralamide1889 sulphonal1889 uralium1889 ural1891 thymacetin1892 chloralose1893 chloretone1899 hedonal1900 veronal1903 Medinal1908 barbitone1914 barbital1919 Sedormid1928 benzodiazepine1934 hexobarbital1941 hexobarbitone1941 glutethimide1955 Placidyl1955 Mogadon1956 chlordiazepoxide1960 nitrazepam1965 flurazepam1968 medazepam1968 lorazepam1969 Rohypnol1971 flunitrazepam1973 triazolam1973 methapyrilene1974 Halcion1975 1934 Chem. Abstr. 28 8031 C₆-C₅N₂ Benzodiazepine. 1960 Jrnl. Pharmacol. & Exper. Therapeutics 129 163/1 Methaminodiazepoxide HCl (Librium HCl) is a psychosedative drug of a new chemical type... Methaminodiazepoxide..is 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide hydrochloride. 1961 Current Therapeutic Res. III. 424 Valium is a new psychotherapeutic agent in the 1,4-benzodiazepine class. 1968 Chem. Rev. 68 748/1 The 1,4-benzodiazepines form the most extensively explored group in this series, largely owing to the discovery of their interesting biological activity, which has led to the introduction of four drugs... The 1,5-benzodiazepines have been thoroughly studied during a period of several decades, largely because of their relatively easy synthesis. 1976 Lancet 30 Oct. 936/2 Barbiturates or benzodiazepines were given to ensure sleep during the preceding night. 1984 A. Smith Mind iv. xiv. 265 Over sixty million prescriptions for benzodiazepines are filled in annually. This entry has not yet been fully updated (first published 1972; most recently modified version published online March 2020). < n.1934
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