quinolonen.

Brit.

/ˈkwɪnələʊn/, U.S.

/ˈkwɪnəˌloʊn/

Origin: Formed within English, by derivation; modelled on a German lexical item. Etymons: quinoline n., -one suffix.

Etymology: < quinol- (in quinoline n.) + -one suffix, after German Chinolon (H. Decker 1892, in Jrnl. f. prakt. Chem. 153 164).

Chemistry and Pharmacology.

Any of various compounds which are oxidized derivatives of quinoline containing an oxygen atom bonded to the pyridine ring; spec. any of a group of antibiotics containing a 4-oxo-1,4 dihydroquinoline skeleton, which are used chiefly against Gram-negative bacteria.

ΚΠ

1892 Jrnl. Chem. Soc. 62 729 When quinoline methyl hydroxide is oxidised with an alkaline solution of potassium ferricyanide, it is converted into 1ˈ-methyl-α-quinolone.

1907 Jrnl. Amer. Chem. Soc. 29 523 Nitrogen ethers of α-quinolones do not form iodomethylates even when heated, on account of their true amide structure (differing in this respect from the γ-quinolones).

1981 Jrnl. Antimicrobial Chemotherapy 7 331 The in vitro activity of rosoxacin, a pyridyl quinolone derivative against Neisseria gonorrhoeae is compared with that of penicillin, cefuroxime and tetracycline.

2001 Guardian 8 Nov. (Online section) 9/3 Whereas some antibacterials are produced from other microbes, quinolones are totally synthetic drugs.

This is a new entry (OED Third Edition, December 2007; most recently modified version published online March 2022).

单词	quinolone
释义	quinolonen. Brit. /ˈkwɪnələʊn/, U.S. /ˈkwɪnəˌloʊn/ Origin: Formed within English, by derivation; modelled on a German lexical item. Etymons: quinoline n., -one suffix. Etymology: < quinol- (in quinoline n.) + -one suffix, after German Chinolon (H. Decker 1892, in Jrnl. f. prakt. Chem. 153 164). Chemistry and Pharmacology. Any of various compounds which are oxidized derivatives of quinoline containing an oxygen atom bonded to the pyridine ring; spec. any of a group of antibiotics containing a 4-oxo-1,4 dihydroquinoline skeleton, which are used chiefly against Gram-negative bacteria. ΚΠ 1892 Jrnl. Chem. Soc. 62 729 When quinoline methyl hydroxide is oxidised with an alkaline solution of potassium ferricyanide, it is converted into 1ˈ-methyl-α-quinolone. 1907 Jrnl. Amer. Chem. Soc. 29 523 Nitrogen ethers of α-quinolones do not form iodomethylates even when heated, on account of their true amide structure (differing in this respect from the γ-quinolones). 1981 Jrnl. Antimicrobial Chemotherapy 7 331 The in vitro activity of rosoxacin, a pyridyl quinolone derivative against Neisseria gonorrhoeae is compared with that of penicillin, cefuroxime and tetracycline. 2001 Guardian 8 Nov. (Online section) 9/3 Whereas some antibacterials are produced from other microbes, quinolones are totally synthetic drugs. This is a new entry (OED Third Edition, December 2007; most recently modified version published online March 2022). < n.1892
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