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单词 protopathic bias
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protopathic bias
protopathic bias n. Medicine bias introduced into a clinical study by subjects who have an undiagnosed disease.
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1979 R. Horwitz & A. Feinstein in Amer. Jrnl. Med. 66 556 The standards include a predetermined method of patient selection.., unbiased collection of data..and avoidance of protopathic bias in the compared groups.
1991 Jrnl. Clin. Epidemiol. 44 941 Previous studies have found an inverse relation between alcohol use and clinical gallstone disease, suggestive of a protective effect of alcohol use. However, [this may]..be explained by a reduction of alcohol use because of symptoms related to clinical gallstone disease (protopathic bias).
2004 H. M. Kremers & S. E. Gabriel in E. W. St. Clair et al. Rheumatoid Arthritis i. 6/1 A number of limitations exist within this study, including that of protopathic bias (i.e., that self-selection occurs for estrogen therapy at the menopause of those with undiagnosed joint symptoms).
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