Editorial misreading (in R. Napier's edition (1882) of A Noble Boke off Cookry) of pilote, Middle English variant of pelletn.1 (see forms at that entry), taken by N.E.D. (1906) to show a noun pilole with the sense ‘a small ball, a pill’.
This entry has been updated (OED Third Edition, March 2006; most recently modified version published online December 2019).