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单词 niemann–pick
释义

Niemann–Pickn.

Brit. /ˌniːmənˈpiːk/, U.S. /ˌnimənˈpik/
Origin: From proper names. Etymons: proper name Niemann, Pick.
Etymology: < the names of Albert Niemann (1880–1921) and Ludwig Pick (1868–1944), German physicians, who described the disease in 1914 and 1926 respectively. Compare German Niemann-Picksche Krankheit (1928 or earlier), French maladie de Niemann-Pick (1928 or earlier).Niemann described the first case of this disorder in 1914 ( Jahrb. f. Kinderheilkunde 79 1). The disorder was more extensively described and differentiated from other storage disorders by Pick in a series of papers in German medical journals from 1924 to 1927.
Medicine.
attributive, in the genitive, and (rare) with of. Designating, relating to, or suffering from any of a group of inherited (autosomal recessive) metabolic disorders characterized by the abnormal accumulation of lipid (esp. sphingomyelin) in various tissues of the body (chiefly the brain, liver, and spleen), leading in the most severe form (type A) to retardation of physical and mental growth and death in early childhood.Niemann-Pick disease types A and B are caused by a deficiency of the enzyme acid sphingomyelinase. Niemann-Pick type C represents a defect in intracellular cholesterol movement.
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the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [noun] > other metabolic disorders
xanthomatosis1900
Tay-Sachs1907
ketosis1917
protein shock1917
hyperinsulinism1924
Niemann–Pick1928
tyrosinosis1932
von Gierke's disease1933
phenylketonuria1935
cystic fibrosis1938
mucoviscidosis1945
cystinosis1949
oxalosis1952
McArdle1957
orotic aciduria1959
PKU1961
sphingolipidosis1962
Reye's syndrome1965
Menkes1969
1928 Jrnl. Amer. Med. Assoc. 7 Apr. 1166/1 (heading) Niemann–Pick disease... This is the first case of Niemann–Pick's disease to be reported in France.
1928 Arch. Pathol. 6 827 (title) The histogenesis of essential lipoid histiocytosis (Niemann-Pick's disease).
1936 Proc. Royal Soc. Med. 29 585 The three principal types of these lipoidoses are Schüller-Christian's disease, the spleno-hepatomegaly of Gaucher and the spleno-hepatomegaly of Niemann-Pick.
1942 M. M. Wintrobe Clin. Hematol. xii. 521 The cells of Niemann–Pick's disease are round, oval, or polyhedral and are filled with small round hyaline droplets in clusters which give the appearance of foam or a honeycomb.
1973 Sci. Amer. Aug. 90/3 Another disorder involving enlargement of the liver and the spleen and mental retardation, Niemann–Pick disease, was shown..to involve the accumulation of the phospholipid sphingomyelin.
1990 Lab. Investig. 63 385 The levels of the same sugars were elevated in both Gaucher and Niemann-Pick type C patients.
This entry has been updated (OED Third Edition, September 2003; most recently modified version published online March 2022).
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n.1928
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