nesidioblastosisn.

Brit.

/nᵻˌsɪdɪə(ʊ)blasˈtəʊsɪs/, U.S.

/nəˌsɪdɪoʊˌblæsˈtoʊsəs/

Origin: Formed within English, by derivation. Etymons: nesidioblast n., -osis suffix.

Etymology: < nesidioblast n. + -osis suffix.

Medicine.

A rare condition caused by the excessive proliferation of nesidioblast cells in the islets of Langerhans (though not forming a discrete tumour), most cases of which are found as a developmental abnormality in infants, and result in hyperinsulinaemia and hypoglycaemia.

ΚΠ

1938 G. F. Laidlaw in Amer. Jrnl. Pathol. 14 131 There is some evidence pointing to a diffuse or disseminated proliferation of islet cells as a possible cause of hypoglycemia. Such a diffuse proliferation of nesidioblasts would be a nesidioblastosis.

1980 Lancet 5 Apr. 777/1 The unchanged blood glucose values that we found during infusion of cyclic somatostatin show that the beta cell may be more sensitive than the alpha cell to somatostatin suppression, as previously suggested in nesidioblastosis.

1991 Chinese Med. Jrnl. 104 261/2 There exists a full spectrum of conditions ranging from the original nesidioblastosis to islet cell hyperplasia, adenomatosis and true islet cell adenoma.

2001 Arch Surg. 136 656 Nesidioblastosis is an uncommon but clinically important cause of hypoglycemia in the adult population.

This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	nesidioblastosis
释义	nesidioblastosisn. Brit. /nᵻˌsɪdɪə(ʊ)blasˈtəʊsɪs/, U.S. /nəˌsɪdɪoʊˌblæsˈtoʊsəs/ Origin: Formed within English, by derivation. Etymons: nesidioblast n., -osis suffix. Etymology: < nesidioblast n. + -osis suffix. Medicine. A rare condition caused by the excessive proliferation of nesidioblast cells in the islets of Langerhans (though not forming a discrete tumour), most cases of which are found as a developmental abnormality in infants, and result in hyperinsulinaemia and hypoglycaemia. ΚΠ 1938 G. F. Laidlaw in Amer. Jrnl. Pathol. 14 131 There is some evidence pointing to a diffuse or disseminated proliferation of islet cells as a possible cause of hypoglycemia. Such a diffuse proliferation of nesidioblasts would be a nesidioblastosis. 1980 Lancet 5 Apr. 777/1 The unchanged blood glucose values that we found during infusion of cyclic somatostatin show that the beta cell may be more sensitive than the alpha cell to somatostatin suppression, as previously suggested in nesidioblastosis. 1991 Chinese Med. Jrnl. 104 261/2 There exists a full spectrum of conditions ranging from the original nesidioblastosis to islet cell hyperplasia, adenomatosis and true islet cell adenoma. 2001 Arch Surg. 136 656 Nesidioblastosis is an uncommon but clinically important cause of hypoglycemia in the adult population. This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022). < n.1938
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