naloxonen.

Brit.

/nəˈlɒksəʊn/, U.S.

/nəˈlɑkˌsoʊn/

Origin: Formed within English, by derivation. Etymons: nalorphine n., hydroxy- comb. form, English -one.

Etymology: < nal- (in nalorphine n.) + -ox- (in hydroxy- comb. form) + -one (see -one suffix), as shortened form of N-allylnoroxymorphone, an alternative name for the compound.

Pharmacology.

A synthetic opioid antagonist which resembles nalorphine in its chemical structure and is given intravenously (usually in the form of its hydrochloride) in the treatment of opioid overdosage; (−)-(5R,14S)-9a-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one, C₁₉H₂₁NO₄.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > narcotic antagonists

Nalline1952

nalorphine1953

naloxone1964

naltrexone1973

1964 Amer. Jrnl. Med. Sci. 247 412 The n-allyl derivative of oxymorphone (Numorphan) has recently been synthesized and found to be a potent narcotic antagonist... It has also been suggested that this preparation (Naloxone), differs from other narcotic antagonists in that its administration simultaneously with a narcotic results in antagonism of the respiratory depression but not of the analgesia induced by the narcotic.

1978 D. Francis Trial Run xi. 153 As far as I could make out, it said 0.4 mg naloxone, which was spectacularly unhelpful, as I'd never heard of the stuff.

1989 Adverse Drug Reactions & Acute Poisoning Rev. 8 103 Naloxone has been demonstrated to antagonize GABA in both human and rat central nervous systems.

1999 Chem. in Brit. Mar. 22/3 Naloxone and Naltrexone are not ‘substitutes’, rather they are used once detoxification has been completed with the purpose of preventing relapse.

This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022).

单词	naloxone
释义	naloxonen. Brit. /nəˈlɒksəʊn/, U.S. /nəˈlɑkˌsoʊn/ Origin: Formed within English, by derivation. Etymons: nalorphine n., hydroxy- comb. form, English -one. Etymology: < nal- (in nalorphine n.) + -ox- (in hydroxy- comb. form) + -one (see -one suffix), as shortened form of N-allylnoroxymorphone, an alternative name for the compound. Pharmacology. A synthetic opioid antagonist which resembles nalorphine in its chemical structure and is given intravenously (usually in the form of its hydrochloride) in the treatment of opioid overdosage; (−)-(5R,14S)-9a-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one, C₁₉H₂₁NO₄. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > narcotic antagonists Nalline1952 nalorphine1953 naloxone1964 naltrexone1973 1964 Amer. Jrnl. Med. Sci. 247 412 The n-allyl derivative of oxymorphone (Numorphan) has recently been synthesized and found to be a potent narcotic antagonist... It has also been suggested that this preparation (Naloxone), differs from other narcotic antagonists in that its administration simultaneously with a narcotic results in antagonism of the respiratory depression but not of the analgesia induced by the narcotic. 1978 D. Francis Trial Run xi. 153 As far as I could make out, it said 0.4 mg naloxone, which was spectacularly unhelpful, as I'd never heard of the stuff. 1989 Adverse Drug Reactions & Acute Poisoning Rev. 8 103 Naloxone has been demonstrated to antagonize GABA in both human and rat central nervous systems. 1999 Chem. in Brit. Mar. 22/3 Naloxone and Naltrexone are not ‘substitutes’, rather they are used once detoxification has been completed with the purpose of preventing relapse. This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022). < n.1964
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