单词 | myelodysplasia |
释义 | myelodysplasian. Medicine. 1. Abnormal development of the spinal cord, esp. in the lumbar or lumbo-sacral region. ΚΠ 1916 Amer. Jrnl. Med. Sci. 151 470 Most cases of enuresis nocturna, he thinks, can not be attributed to myelodysplasia. 1964 Jrnl. Bone & Joint Surg. 46A 1577 The term myelodysplasia is now used to describe a wide variety of clinical syndromes which include a developmental defect of the spinal cord associated with a peripheral neurological defect involving the lumbar or lumbosacral region. 1994 Muscle & Nerve 17 1214 Most patients with complete thoracolumbar myelodysplasia appear clinically to have complete lower motor neuron lesions. 2. Abnormal development of one or more types of blood cell (erythrocytes, leukocytes, or thrombocytes); any of a group of disorders characterized by this, presenting with anaemia, leukopenia, or thrombocytopenia (or any combination of these), and sometimes progressing to acute myeloid leukaemia. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > other blood disorders diacrisis1684 melanaema1788 mal-crasis1854 saturation1872 myeloid metaplasia1931 abetalipoproteinaemia1960 acanthocytosis1960 myelodysplasia1966 1966 J. D. Rowley et al. in Blood 27 782 The myelodysplasias refer to a group of disorders exhibiting morphologic evidence in the marrow and the blood of disturbed formation of any, or any combination, of the major blood cell lineages (erythroid, granulocytic, megakaryotic), not characteristic of the aplastic, the myeloproliferative, or the leukemic states, yet displaying features often intermediate or transitional between these conditions. 1987 Brit. Med. Jrnl. 11 Apr. 938/1 A higher incidence of other cancers occurring before the diagnosis of myelodysplasia may have been obscured by death before the haematological abnormality was identified. 1993 Latest Word Dec. 28/1 Potential applications for CSFs [sc. colony stimulating factors] include boosting of immune system response; treatment of..myelodysplasia, leukemia..and..neutropenia. This is a new entry (OED Third Edition, June 2003; most recently modified version published online March 2022). < n.1916 |
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