methotrexaten.

Brit.

/ˌmɛθə(ʊ)ˈtrɛkseɪt/,

/ˌmiːθə(ʊ)ˈtrɛkseɪt/, U.S.

/ˌmɛθəˈtrɛkˌseɪt/

Origin: Formed within English, by derivation. Etymons: methyl n., -o- connective, English trex- , -ate suffix⁴.

Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + -o- connective + trex- (origin unknown) + -ate suffix⁴.

Pharmacology.

A folate antagonist used as an antineoplastic and immunosuppressive drug; 4-amino-10-methylfolic acid, C₂₀H₂₂N₈O₅. Also called amethopterin.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia

amethopterin1948

Myleran1952

Laetrile1953

thioguanine1953

thioTEPA1953

mercaptopurine1954

methotrexate1955

busulfan1956

chlorambucil1956

cyclophosphamide1960

vinblastine1962

vincristine1962

levamisole1969

vinca alkaloid1970

doxorubicin1971

tamoxifen1972

Airol1974

trastuzumab1997

thiotepa-

1955 Sci. News Let. 5 Feb. 88/2 The new drug is an anti-folic acid compound very similar to Aminopterin. It is called Methotrexate by its manufacturers, Lederle Laboratories, Pearl River, N.Y.

1961 Lancet 7 Oct. 821/1 Methotrexate..and mercaptopurine..are folic-acid antagonists, which..interfere with nucleic-acid synthesis by inhibiting folic-acid reductase.

1970 Times Lit. Suppl. 26 Mar. 332/4 Burkett's [read Burkitt's] tumour..can be treated easily and successfully by dosing with methotrexate.

1971 Nature 22 Oct. 518/3 The Food and Drug Administration has decided to allow the controversial drug methotrexate to be used for severe cases of psoriasis.

1981 M. C. Gerald Pharmacol. (ed. 2) xxx. 585 Methotrexate, employed alone or in combination with other drugs, has produced remission in the symptoms of acute leukemia up to several years.

1991 N. Baker U & I ix. 177 He had switched to the grandmaster drug methotrexate, the liver-witherer, while I hung fire with PUVA.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methotrexate
释义	methotrexaten. Brit. /ˌmɛθə(ʊ)ˈtrɛkseɪt/, /ˌmiːθə(ʊ)ˈtrɛkseɪt/, U.S. /ˌmɛθəˈtrɛkˌseɪt/ Origin: Formed within English, by derivation. Etymons: methyl n., -o- connective, English trex- , -ate suffix⁴. Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + -o- connective + trex- (origin unknown) + -ate suffix⁴. Pharmacology. A folate antagonist used as an antineoplastic and immunosuppressive drug; 4-amino-10-methylfolic acid, C₂₀H₂₂N₈O₅. Also called amethopterin. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia amethopterin1948 Myleran1952 Laetrile1953 thioguanine1953 thioTEPA1953 mercaptopurine1954 methotrexate1955 busulfan1956 chlorambucil1956 cyclophosphamide1960 vinblastine1962 vincristine1962 levamisole1969 vinca alkaloid1970 doxorubicin1971 tamoxifen1972 Airol1974 trastuzumab1997 thiotepa- 1955 Sci. News Let. 5 Feb. 88/2 The new drug is an anti-folic acid compound very similar to Aminopterin. It is called Methotrexate by its manufacturers, Lederle Laboratories, Pearl River, N.Y. 1961 Lancet 7 Oct. 821/1 Methotrexate..and mercaptopurine..are folic-acid antagonists, which..interfere with nucleic-acid synthesis by inhibiting folic-acid reductase. 1970 Times Lit. Suppl. 26 Mar. 332/4 Burkett's [read Burkitt's] tumour..can be treated easily and successfully by dosing with methotrexate. 1971 Nature 22 Oct. 518/3 The Food and Drug Administration has decided to allow the controversial drug methotrexate to be used for severe cases of psoriasis. 1981 M. C. Gerald Pharmacol. (ed. 2) xxx. 585 Methotrexate, employed alone or in combination with other drugs, has produced remission in the symptoms of acute leukemia up to several years. 1991 N. Baker U & I ix. 177 He had switched to the grandmaster drug methotrexate, the liver-witherer, while I hung fire with PUVA. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1955
随便看	to do or have diligence to do or make a blenk or blench to do or make cost to do or make costs to do or make deray to to do or make gree to do or make ligeance to do or make one's ligeance to do or make the cost to do or make the costs to do or pay one's devoir to do or pay one's devoirs (to some one to do or perform wonders to do or put up, to let down hair to do or put up, to let down one's hair to do or work wough to do out to do out of to do outrage to do over to do paddy doyle to do penance to do pleasing to do pooly to do puja