megaloblastn.
/ˈmɛɡələ(ʊ)blɑːst/, /ˈmɛɡələ(ʊ)blast/, /ˈmɛɡl̩ə(ʊ)blɑːst/, /ˈmɛɡl̩ə(ʊ)blast/, U.S. /ˈmɛɡ(ə)loʊˌblæst/, /ˈmɛɡ(ə)ləˌblæst/ Medicine.
An abnormally large erythroblast, characteristic esp. of certain types of anaemia.
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the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > disorders of red cells > abnormal red cell
microcyte1876
megalocyte1886
macrocyte1889
megaloblast1890
gigantoblast1898
spherocyte1908
target cell1938
1890 G. M. Gould New Med. Dict. 119/2 Corpuscles of the blood have been distinguished, according to their size—into normoblasts (normal in size), megaloblasts of excessive size [etc.].
1890 J. Cagney tr. R. von Jaksch Clin. Diagnosis i. 25 Microcytes and megaloblasts are also not of rare occurrence.
1929 R. B. H. Gradwohl tr. V. Schilling Blood Pictures ii. 113 Single or many large hyperchromatic cells (megalocytes, occasional megaloblasts).
1967 Brain 90 41 Sternal marrow—mainly normoblastic erythropoiesis, with a few megaloblasts.
1990 Amer. Jrnl. Pediatric Hematol.–Oncol. 12 194 Bone marrow examination revealed marked erythroid hypoplasia and giant megaloblasts without evidence of relapse.
This entry has been updated (OED Third Edition, June 2001; most recently modified version published online March 2022).
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n.1890