megakaryoblastn.
/ˌmɛɡəˈkarɪə(ʊ)blɑːst/, /ˌmɛɡəˈkarɪə(ʊ)blast/, U.S. /ˌmɛɡəˈkɛrioʊˌblæst/, /ˌmɛɡəˈkɛriəˌblæst/ Physiology.
A cell which develops into a megakaryocyte.
ΚΠ
1948 Amer. Jrnl. Clin. Pathol. 18 449 Megakaryoblast, any cell of the thrombocytic series having a nucleus with fine chromatin structure. Usually these are larger than the other blast cells.
1956 E. Ponder tr. M. Bessis Cytol. Blood & Blood-forming Organs xi. 449 Cells of the megakaryoblast type are very small in number in comparison with other cells of the marrow.
1976 Blut 32 433 Even in cases without evidence of myelofibrosis under the light microscope, megakaryoblasts were associated with fibrillar structures.
1985 C. R. Leeson et al. Textbk. Histol. (ed. 5) v. 166/1 Megakaryoblasts differentiate into megakaryocytes by a peculiar form of nuclear division in which the nucleus undergoes multiple mitotic divisions without cytoplasmic division.
Derivatives
megakaryoˈblastic adj.
ΚΠ
1975 Cancer 36 576 A case of megakaryoblastic leukemia.
1999 Jrnl. Pediatr. Hematol.–Oncol. 21 428 Chromosomal translocations..have been reported to occur in a number of infants with acute megakaryoblastic leukemia.
This is a new entry (OED Third Edition, June 2001; most recently modified version published online March 2022).
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