autophagicadj.
/ˌɔːtəˈfeɪdʒɪk/, /ˌɔːtəˈfadʒɪk/, U.S. /ˌɔdoʊˈfædʒɪk/, /ˌɔdoʊˈfeɪdʒɪk/, /ˌɑdoʊˈfædʒɪk/, /ˌɑdoʊˈfeɪdʒɪk/ 1. = autophagous adj. 2. Now rare.
ΚΠ
1866 N.Y. Med. Jrnl. 2 473 Our own observations have inclined us to entertain the belief that camp diarrhœa was a chronic autophagic disease.
1872 New Eng. Med. & Surg. Jrnl. 13 June 386/2 Thus, though all diabetics are to a certain extent autophagic, we may yet have this abnormality developed to excess.
1887 Lancet 16 Apr. 804 The breath has not the autophagic odour of insanity and starvation.
1921 J. H. Kellogg New Dietetics 596 He [sc. a fasting person] is not only a flesh eater but a cannibal and even worse, he is autophagic.
2. Cell Biology. Of, relating to, or involved in the cellular process of autophagy (autophagy n. 2).
ΚΠ
1963 C. de Duve in A. V. S. de Reuck & M. P. Cameron Lysosomes 26 The autolytic (autophagic) vacuoles or cytolysomes..have been found to stain positively for acid phosphatase.
1974 J. B. Finean et al. Membranes & Cellular Functions v. 78 Autophagic activity is often prominent during times of change in metabolic emphasis (e.g. regression of tissue).
1990 Jrnl. Exper. Bot. 41 969/2 Protein bodies appear to be the main lytic compartment of storage parenchyma cells and may operate as autophagic organelles during germination.
2008 Nature 28 Feb. 1069 The capacity for large-scale degradation is important in autophagic function, but it carries a certain risk, because unregulated degradation of the cytoplasm is likely to be lethal.
Compounds
autophagic vacuole n. Cell Biology = autophagosome n.
ΘΚΠ
the world > life > biology > substance > cell > cell organelle or contents > [noun] > vacuole
vacuole1853
vacuome1926
phagosome1958
autophagic vacuole1963
autophagosome1965
1963 C. de Duve in A. V. S. de Reuck & M. P. Cameron Lysosomes 26 The autolytic (autophagic) vacuoles or cytolysomes..have been found to stain positively for acid phosphatase.
1991 Acta Neuropathologica 81 498/1 Other fibers presented numerous small vacuoles and some large autophagic vacuoles containing pseudomyelinic bodies and cytoplasmic debris.
2005 Proc. National Acad. Sci. U.S.A. 40 14466/2 No labeling was detected in the autophagic vacuoles, typical organelles of the PCD [= programmed cell death] pathway responsible for cell content autodestruction.
This is a new entry (OED Third Edition, June 2011; most recently modified version published online December 2021).
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adj.1866