manoaliden.

Brit.

/məˈnəʊəlʌɪd/, U.S.

/məˈnoʊəˌlaɪd/

Origin: From a proper name, combined with English elements. Etymons: proper name Manoa , English -l- , -ide suffix.

Etymology: < the name of Manoa Valley, Oahu, where the compound was first isolated + -l- + -ide suffix (see quot. 1980). The -l- preceding the suffix is probably arbitrary.

Biochemistry.

A terpenoid compound, C₂₅H₃₆0₅, originally isolated from a marine sponge, which is a non-steroidal anti-inflammatory agent and a potent inhibitor of some phospholipase enzymes.

ΚΠ

1980 E. D. de Silva & P. J. Scheuer in Tetrahedron Lett. 21 1611 We now wish to report isolation and structure of a pentaprenoid with identical end groups but with one C₅ moeity cyclyzed to an α,β–unsaturated δ–lactol function. The structure of this compound, which we are naming manoalide, is based on the following data.

1987 Jrnl. Biol. Chem. 262 6531 Manoalide is a marine natural product that has anti-inflammatory and anti-proliferative activities and is an irreversible inhibitor of phospholipase A2 and phospholipase C.

1995 Chem. in Brit. Sept. 683/1 The first compound that we studied in detail was manoalide, from the sponge Luffariella variabilis.

This is a new entry (OED Third Edition, September 2000; most recently modified version published online March 2022).

单词	manoalide
释义	manoaliden. Brit. /məˈnəʊəlʌɪd/, U.S. /məˈnoʊəˌlaɪd/ Origin: From a proper name, combined with English elements. Etymons: proper name Manoa , English -l- , -ide suffix. Etymology: < the name of Manoa Valley, Oahu, where the compound was first isolated + -l- + -ide suffix (see quot. 1980). The -l- preceding the suffix is probably arbitrary. Biochemistry. A terpenoid compound, C₂₅H₃₆0₅, originally isolated from a marine sponge, which is a non-steroidal anti-inflammatory agent and a potent inhibitor of some phospholipase enzymes. ΚΠ 1980 E. D. de Silva & P. J. Scheuer in Tetrahedron Lett. 21 1611 We now wish to report isolation and structure of a pentaprenoid with identical end groups but with one C₅ moeity cyclyzed to an α,β–unsaturated δ–lactol function. The structure of this compound, which we are naming manoalide, is based on the following data. 1987 Jrnl. Biol. Chem. 262 6531 Manoalide is a marine natural product that has anti-inflammatory and anti-proliferative activities and is an irreversible inhibitor of phospholipase A2 and phospholipase C. 1995 Chem. in Brit. Sept. 683/1 The first compound that we studied in detail was manoalide, from the sponge Luffariella variabilis. This is a new entry (OED Third Edition, September 2000; most recently modified version published online March 2022). < n.1980
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