leprolinn.
/ˈlɛprəlɪn/, U.S. /ˈlɛprələn/ Medicine.
Originally: a preparation supposedly derived from cultures of Mycobacterium leprae, used in attempts to treat and prevent leprosy (now historical). In later use: any of several preparations containing proteins of M. leprae, used in skin testing for the classification of cases of leprosy. Cf. lepromin n.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > [noun] > drugs used as testing agents
tuberculin1891
lepromin1929
penatin1942
sulphobromophthalein1945
toxoplasmin1948
Metopirone1960
metyrapone1962
leprolin1971
1904 E. R. Rost in Indian Med. Gaz. 39 168/2 The next thing that was attempted was the manufacture of a leprolin on the lines of the manufacture of tuberculin.
1934 Brit. Med. Jrnl. 21 Apr. 703/2 The typical reaction to leprolin..when applied to healthy persons in an area free from endemic leprosy, differs from the intracutaneous tuberculin reaction in remaining for some days negative or doubtful.
1971 Internat. Jrnl. Leprosy 39 719/2 We deemed it worthwhile to determine the capacity of lymphocytes from leprosy patients to produce lymphotoxin in the presence of PHA and leprolin.
1987 Serodiagnosis & Immunotherapy 1 402/1 In 1904, Major Rost with the British Army in Burma developed a vaccine treatment, which he called ‘leprolin’, derived from ‘cultures of the leprosy bacillus’ isolated from the cotton shirt of a leper.
2005 Clin. Neurol. & Neurosurg. 107 449/2 It [sc. the lepromin test] is a measure of delayed-type hypersensitivity of the individual to M. leprae antigens, which may be in the form of integral lepromin, Dharmendra antigen, leprolin, or leprosin.
This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022).
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n.1904