l-dopan.

/ɛlˈdəʊpə/

Forms: Also l- (now rare), L-, -DOPA.

Etymology: < L n. 6c + dopa n.

Chemistry and Biochemistry.

= levodopa n.

ΚΠ

1939 Jrnl. Physiol. 96 51 P Tyrosine given in the diet is partly excreted as l-dopa.

1942 Jrnl. Physiol. 101 345 In tyrosinosis l(−)-dopa was found to be excreted in the urine after oral administration of l(−)-tyrosine.

1958 Brit. Jrnl. Pharmacol. 13 92/1 (heading) Effect of l-dopa and epinine.

1969 3rd Symposium Parkinson's Dis. (Royal Coll. Surg. Edinb.) 178 L-Dihydroxyphenylalanine (L-dopa) proved far less toxic and more effective than the racemic compound studied earlier.

1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. v. 61/2 [In Parkinsonism] DOPA is given by mouth in doses up to 16 g/day of the racemic mixture or up to 8 g of l-DOPA.

1970 D. B. Calne Parkinsonism x. 94 Disappointing results arise from unwanted effects of l-dopa, such as dyskinesia or psychiatric disturbances.

1970 Times 29 Apr. 2/3 l-Dopa, the drug used experimentally in treatment of Parkinson's Disease, has passed the clinical trial stage.

This entry has not yet been fully updated (first published 1976; most recently modified version published online December 2020).

单词	l-dopa
释义	l-dopan. /ɛlˈdəʊpə/ Forms: Also l- (now rare), L-, -DOPA. Etymology: < L n. 6c + dopa n. Chemistry and Biochemistry. = levodopa n. ΚΠ 1939 Jrnl. Physiol. 96 51 P Tyrosine given in the diet is partly excreted as l-dopa. 1942 Jrnl. Physiol. 101 345 In tyrosinosis l(−)-dopa was found to be excreted in the urine after oral administration of l(−)-tyrosine. 1958 Brit. Jrnl. Pharmacol. 13 92/1 (heading) Effect of l-dopa and epinine. 1969 3rd Symposium Parkinson's Dis. (Royal Coll. Surg. Edinb.) 178 L-Dihydroxyphenylalanine (L-dopa) proved far less toxic and more effective than the racemic compound studied earlier. 1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. v. 61/2 [In Parkinsonism] DOPA is given by mouth in doses up to 16 g/day of the racemic mixture or up to 8 g of l-DOPA. 1970 D. B. Calne Parkinsonism x. 94 Disappointing results arise from unwanted effects of l-dopa, such as dyskinesia or psychiatric disturbances. 1970 Times 29 Apr. 2/3 l-Dopa, the drug used experimentally in treatment of Parkinson's Disease, has passed the clinical trial stage. This entry has not yet been fully updated (first published 1976; most recently modified version published online December 2020). < n.1939
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