idiotopen.

Brit.

/ˈɪdɪəˌtəʊp/, U.S.

/ˈɪdiəˌtoʊp/

Origin: Formed within English, by compounding. Etymons: idio- comb. form, epitope n.

Etymology: < idio- comb. form + -tope (in epitope n.). In sense 2 after idiotypic adj. (see sense 3 at that entry).

Immunology.

1. An epitope characteristic of an individual animal. rare. Now disused.

ΚΠ

1960 N. K. Jerne in Ann. Rev. Microbiol. 14 342 Epitopes that are carried by components of one individual animal are idiotopes. The idiotypes to which they belong constitute the idiom of the animal.

1971 W. J. Halliday Gloss. Immunol. Terms 25 Idiotope, an epitope carried by an antigen characteristic of one individual animal.

2. An epitope present in the variable region of an immunoglobulin (antibody) molecule, often as part of the antigen-binding site.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > idiotope

idiotype1967

idiotope1973

1973 N. K. Jerne in Sci. Amer. July 59/1 When antibodies produced by animal A are injected into animal B, animal B will produce antibodies against the idiotypic epitopes (‘idiotopes’) of the injected antibody molecules.

1989 Brit. Jrnl. Haematol. 72 155/1 The level of expression of the idiotopes recognized by antibodies 44.2A1 and 2H3.D6 in CLL is sufficient to make clinical trials with pre-formed antibodies against shared idiotopes a practical proposition.

2008 Appl. Soft Computing 8 1043/1 According to the immune network theory, the receptor molecules contained in the surface of the immune cells present markers, named idiotopes.

This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022).

单词	idiotope
释义	idiotopen. Brit. /ˈɪdɪəˌtəʊp/, U.S. /ˈɪdiəˌtoʊp/ Origin: Formed within English, by compounding. Etymons: idio- comb. form, epitope n. Etymology: < idio- comb. form + -tope (in epitope n.). In sense 2 after idiotypic adj. (see sense 3 at that entry). Immunology. 1. An epitope characteristic of an individual animal. rare. Now disused. ΚΠ 1960 N. K. Jerne in Ann. Rev. Microbiol. 14 342 Epitopes that are carried by components of one individual animal are idiotopes. The idiotypes to which they belong constitute the idiom of the animal. 1971 W. J. Halliday Gloss. Immunol. Terms 25 Idiotope, an epitope carried by an antigen characteristic of one individual animal. 2. An epitope present in the variable region of an immunoglobulin (antibody) molecule, often as part of the antigen-binding site. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > idiotope idiotype1967 idiotope1973 1973 N. K. Jerne in Sci. Amer. July 59/1 When antibodies produced by animal A are injected into animal B, animal B will produce antibodies against the idiotypic epitopes (‘idiotopes’) of the injected antibody molecules. 1989 Brit. Jrnl. Haematol. 72 155/1 The level of expression of the idiotopes recognized by antibodies 44.2A1 and 2H3.D6 in CLL is sufficient to make clinical trials with pre-formed antibodies against shared idiotopes a practical proposition. 2008 Appl. Soft Computing 8 1043/1 According to the immune network theory, the receptor molecules contained in the surface of the immune cells present markers, named idiotopes. This entry has been updated (OED Third Edition, November 2010; most recently modified version published online March 2022). < n.1960
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