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hepato-lenticular degeneration
hepato-lenticular degeneration n. 
/ˌhɛpədoʊlɛnˌtɪkjələr diˌdʒɛnəˈreɪʃ(ə)n/, /həˌpædəlɛnˌtɪkjələr dəˌdʒɛnəˈreɪʃ(ə)n/, /həˌpædəlɛnˌtɪkjələr diˌdʒɛnəˈreɪʃ(ə)n/ [translating French dégénérescence hépato-lenticulaire (H. C. Hall, 1921)] a progressive disease of the nervous system (see quot. 1955); Wilson's disease.
Brit. /ˌhɛpətə(ʊ)lɛnˌtɪkjᵿlə dᵻˌdʒɛnəˈreɪʃn/
, /ˌhɛpətə(ʊ)lɛnˌtɪkjᵿlə dᵻˌdʒɛnəˈreɪʃn/U.S. /ˌhɛpədoʊlɛnˌtɪkjələr dəˌdʒɛnəˈreɪʃ(ə)n/
, /ˌhɛpədoʊlɛnˌtɪkjələr dəˌdʒɛnəˈreɪʃ(ə)n//ˌhɛpədoʊlɛnˌtɪkjələr diˌdʒɛnəˈreɪʃ(ə)n//həˌpædəlɛnˌtɪkjələr dəˌdʒɛnəˈreɪʃ(ə)n//həˌpædəlɛnˌtɪkjələr diˌdʒɛnəˈreɪʃ(ə)n/ΘΚΠ
the world > health and disease > ill health > a disease > disorders of internal organs > disorders of nervous system > [noun] > other nervous disorders
ciguatera1862
gangliopathy1868
hepato-lenticular degeneration1922
ganglionopathy1952
leukodystrophy1960
smon1971
Tourette('s) syndrome1973
1922 Lancet 29 Apr. 849/2 This is an account of the disease known as progressive lenticular degeneration, which Dr. Hall christens hepato-lenticular degeneration.
1925 Brain 48 332 It would be better to adopt Hall's terminology, and refer to the condition as hepato~lenticular degeneration... This title fails to indicate the peculiar type of the disease in the liver..but it indicates..that the lenticular disease is a sequel to liver damage.
1945 Arch. Internal Med. 75 151/1 Wilson in 1912..first clearly defined the condition now most widely known as hepatolenticular degeneration.
1955 S. Sherlock Dis. Liver & Biliary Syst. xiii. 339 Hepatolenticular degeneration is a rare disease of young people characterised by portal cirrhosis of the liver, bilateral softening and degeneration of the lenticular nuclei of the basal ganglia of the brain, and greenish-brown pigmented rings in the periphery of the cornea.
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