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单词 antisense
释义

antisenseadj.

/ˈæntisɛns/
Etymology: < anti- prefix1 + sense n. Additions.
Biochem. and Genetics.
Designating or pertaining to the strand of duplex DNA that acts as a template for the synthesis of mRNA in a cell; also, designating or pertaining to RNA produced by the transcription of sense DNA, having a complementary base sequence to mRNA and able to bind with it, thereby preventing translation of the latter into protein. Also absol. as n.For an antithetical use see note s.v. sense n. Additions.
ΘΚΠ
the world > life > biology > biological processes > genetic activity > genetic components > [adjective] > DNA or RNA > of parts of DNA
sense1958
redundant1962
nucleosomal1975
antisense1977
the world > life > biology > biological processes > genetic activity > genetic components > [noun] > nucleic acid > DNA > section of
operator1961
satellite1962
junk DNA1963
spacer1963
transposon1974
antisense1977
retroposon1983
retrotransposon1985
retroelement1988
microsatellite1989
1977 Biochem. & Biophys. Res. Communications 75 602 The synthesis of the ‘anti-sense’ strand, and its pairing with globin RNA sequences, are processes that will presumably occur in the absence of Hg-substituted precursors.
1979 Jrnl. Molecular Biol. 135 729 A fraction of h22 transcripts from the oocyte must be considered as erroneous since they are derived from the antisense strand of histone DNA whereas in the sea urchin only the sense strand is transcribed.
1988 Nature 30 June 801/1 Anti-sense RNA..is complementary to a given messenger RNA species, with which it pairs, forming double-stranded RNA.
1990 Food FIPP Apr. 2/2 Antisense tomatoes are engineered with a gene that significantly reduces the naturally occurring enzyme polygalacturonase.
1991 Daily Tel. 27 May 18/5 The scientists inserted an antisense genetic sequence into the chromosomes of fertilised mouse eggs.
1993 W. Bains Biotechnol. 19 Antisense was discovered as the way that some bacteria naturally regulate the activity of some of their genes.
This entry has not yet been fully updated (first published 1997; most recently modified version published online March 2011).
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adj.1977
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