ergotaminen.

/əːˈɡɒtəmiːn/

/əːˈɡɒtəmɪn/

Etymology: < German ergotamin (Spiro & Stoll 1921, in Actes Soc. Helv. Sci. Nat. 1920 235), < ergot n. + amine n.

Biochemistry.

An alkaloid, C₃₃H₃₅O₅N₅, present in some kinds of ergot and used chiefly in the treatment of migraine.

ΚΠ

1921 Brit. Pat. 170, 302 The principal alkaloid of ergot in the pure crystallised state..has since been designated..by the scientific name of ‘ergotamine’.

1952 L. Marion in Manske & Holmes Alkaloids II. 376 Ergotamine and ergotaminine do not seem to occur in rye ergot, but are found in other ergots such as that growing..on marrom grass.

1955 Sci. News Let. 30 July 71/3 The radioactive fungus ergot, and the drugs ergotamine and ergonovine to be extracted from it.

1964 S. Duke-Elder Parsons' Dis. Eye (ed. 14) xxiv. 362 Rest, warmth, and sleep are the best measures to combat the attacks [of migraine]; they can sometimes be warded off or alleviated by ergotamine tartrate.

1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 75 Ergotamine has now lost much of its importance since the discovery of ergometrine (ergonovine).

Derivatives

ergoˈtaminine n. [ < German ergotaminin (Spiro & Stoll 1921, in Actes Soc. Helv. Sci. Nat. 1920 236), < ergot n. + -am- (in amine n.) + -ine suffix⁵] a physiologically inactive ergot alkaloid, isomeric with ergotamine.

ΚΠ

1922 Jrnl. Chem. Soc. A. 122 i. 47 Ergotamine, obtained in crystallisable form from ergot, on treatment with methyl alcohol gives a new, less active alkaloid, ergotaminine.

1961 New Scientist 2 Nov. 278/2 The first pure ergot alkaloids were obtained by Stoll in 1920, namely the pharmacologically-active compound ergotamine and the inactive mirror-image molecule ergotaminine.

This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2018).

单词	ergotamine
释义	ergotaminen. /əːˈɡɒtəmiːn//əːˈɡɒtəmɪn/ Etymology: < German ergotamin (Spiro & Stoll 1921, in Actes Soc. Helv. Sci. Nat. 1920 235), < ergot n. + amine n. Biochemistry. An alkaloid, C₃₃H₃₅O₅N₅, present in some kinds of ergot and used chiefly in the treatment of migraine. ΚΠ 1921 Brit. Pat. 170, 302 The principal alkaloid of ergot in the pure crystallised state..has since been designated..by the scientific name of ‘ergotamine’. 1952 L. Marion in Manske & Holmes Alkaloids II. 376 Ergotamine and ergotaminine do not seem to occur in rye ergot, but are found in other ergots such as that growing..on marrom grass. 1955 Sci. News Let. 30 July 71/3 The radioactive fungus ergot, and the drugs ergotamine and ergonovine to be extracted from it. 1964 S. Duke-Elder Parsons' Dis. Eye (ed. 14) xxiv. 362 Rest, warmth, and sleep are the best measures to combat the attacks [of migraine]; they can sometimes be warded off or alleviated by ergotamine tartrate. 1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 75 Ergotamine has now lost much of its importance since the discovery of ergometrine (ergonovine). Derivatives ergoˈtaminine n. [ < German ergotaminin (Spiro & Stoll 1921, in Actes Soc. Helv. Sci. Nat. 1920 236), < ergot n. + -am- (in amine n.) + -ine suffix⁵] a physiologically inactive ergot alkaloid, isomeric with ergotamine. ΚΠ 1922 Jrnl. Chem. Soc. A. 122 i. 47 Ergotamine, obtained in crystallisable form from ergot, on treatment with methyl alcohol gives a new, less active alkaloid, ergotaminine. 1961 New Scientist 2 Nov. 278/2 The first pure ergot alkaloids were obtained by Stoll in 1920, namely the pharmacologically-active compound ergotamine and the inactive mirror-image molecule ergotaminine. This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2018). < n.1921
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