amethopterinn.

Brit.

/ˌamᵻˈθɒptərɪn/,

/ˌeɪmᵻˈθɒptərɪn/, U.S.

/ˌæməˈθɑptərən/,

/ˌeɪməˈθɑptərən/

Forms: 1900s– A-methopterin, 1900s– a-methopterin, 1900s– amethopterin. Also with capital initial in the second element.

Origin: Formed within English, by compounding. Etymons: amino- comb. form, methyl n., -o- connective, pterin n.

Etymology: < a- (in amino- comb. form) + meth- (in methyl n.) + -o- connective + pterin n.

Pharmacology. Now rare.

The antineoplastic and immunosuppressive drug methotrexate.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia

amethopterin1948

Myleran1952

Laetrile1953

thioguanine1953

thioTEPA1953

mercaptopurine1954

methotrexate1955

busulfan1956

chlorambucil1956

cyclophosphamide1960

vinblastine1962

vincristine1962

levamisole1969

vinca alkaloid1970

doxorubicin1971

tamoxifen1972

Airol1974

trastuzumab1997

thiotepa-

1948 Lancet 27 Nov. 840/1 A-Methopterin.—In this compound there are amino groups in the 2– and 4–positions and a methyl group on the N₁₀.

1949 Ann. Reg. 1948 421 One of the most promising substances [in cancer research] was a synthetic material A-methopterin... It had been shown to inhibit growth of tumours in laboratory animals.

1949 Sci. News Let. 29 Oct. 274/2 The chemicals used are aminopterin, amethopterin, and Amino-An-Fol.

1963 H. Burn Drugs, Med. & Man (ed. 2) xix. 194 Substances closely resembling folic acid in structure are similarly effective in reducing the growth of malignant cells. Two of these are aminopterin and amethopterin.

2000 Proc. National Acad. Sci. U.S.A. 97 14295 One of 10⁶ human leukemic cells is resistant to amethopterin.

This entry has been updated (OED Third Edition, September 2020; most recently modified version published online December 2021).

单词	amethopterin
释义	amethopterinn. Brit. /ˌamᵻˈθɒptərɪn/, /ˌeɪmᵻˈθɒptərɪn/, U.S. /ˌæməˈθɑptərən/, /ˌeɪməˈθɑptərən/ Forms: 1900s– A-methopterin, 1900s– a-methopterin, 1900s– amethopterin. Also with capital initial in the second element. Origin: Formed within English, by compounding. Etymons: amino- comb. form, methyl n., -o- connective, pterin n. Etymology: < a- (in amino- comb. form) + meth- (in methyl n.) + -o- connective + pterin n. Pharmacology. Now rare. The antineoplastic and immunosuppressive drug methotrexate. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia amethopterin1948 Myleran1952 Laetrile1953 thioguanine1953 thioTEPA1953 mercaptopurine1954 methotrexate1955 busulfan1956 chlorambucil1956 cyclophosphamide1960 vinblastine1962 vincristine1962 levamisole1969 vinca alkaloid1970 doxorubicin1971 tamoxifen1972 Airol1974 trastuzumab1997 thiotepa- 1948 Lancet 27 Nov. 840/1 A-Methopterin.—In this compound there are amino groups in the 2– and 4–positions and a methyl group on the N₁₀. 1949 Ann. Reg. 1948 421 One of the most promising substances [in cancer research] was a synthetic material A-methopterin... It had been shown to inhibit growth of tumours in laboratory animals. 1949 Sci. News Let. 29 Oct. 274/2 The chemicals used are aminopterin, amethopterin, and Amino-An-Fol. 1963 H. Burn Drugs, Med. & Man (ed. 2) xix. 194 Substances closely resembling folic acid in structure are similarly effective in reducing the growth of malignant cells. Two of these are aminopterin and amethopterin. 2000 Proc. National Acad. Sci. U.S.A. 97 14295 One of 10⁶ human leukemic cells is resistant to amethopterin. This entry has been updated (OED Third Edition, September 2020; most recently modified version published online December 2021). < n.1948
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