allopurinoln.
/ˌaləʊˈpjʊərᵻnɒl/, U.S. /ˌæloʊˈpjʊrinɑl/ Pharmacology.
A synthetic purine analogue that acts as a competitive inhibitor of the enzyme xanthine oxidase, used esp. in the treatment of gout and other conditions characterized by an abnormally high level of uric acid in the blood and urine.Chemical name: 4-hydroxypyrazolo-[3,4-d]pyrimidine; C5H4N4O.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for arthritis, rheumatism, or gout > others
Portland powder1763
helmitol1903
probenecid1950
indomethacin1963
allopurinol1964
ibuprofen1967
naproxen1971
sulindac1975
1964 Amer. Jrnl. Med. 37 885/2 Our chief interest in testing the new drug, now designated allopurinol, was to determine its efficacy in cases of primary and secondary gout.
1983 D. J. Weatherall et al. Oxf. Textbk. Med. II. xix. 106 In the early stages of treatment [of chronic granulocytic leukaemia].., allopurinol, 400–600 mg daily, should be given.
2008 Independent 5 Feb. (Extra section) 11/2 For the worst affected, experiencing two or more attacks [of gout] a year, allopurinol is the most widely prescribed medicine.
This entry has been updated (OED Third Edition, September 2012; most recently modified version published online December 2021).
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n.1964