diphenoxylaten.
/dʌɪfɛˈnɒksɪleɪt/ Pharmacology.
A tetracyclic derivative, C30H32N2O2, of pethidine that reduces intestinal motility and is given orally as the hydrochloride in cases of diarrhoea and colitis.
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diphenoxylate1960
1960 Amer. Jrnl. Gastroenterol. 34 630 A new antidiarrheal agent, diphenoxylate hydrochloride, Lomotil (R-1132), was administered to 80 patients with diarrhea of various causes.
1976 Brit. Med. Jrnl. 20 Nov. 1240/2 Diphenoxylate with atropine (Lomotil) is popular nowadays.
1984 Brit. National Formulary (Brit. Med. Assoc.) (ed. 8) 53/2 In chronic diarrhoeas..loperamide may be preferable to the centrally acting opiates (morphine, codeine, and diphenoxylate) as it is unlikely to cause dependence.
This entry has not yet been fully updated (first published 1993; most recently modified version published online June 2018).
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n.1960