cyclophosphamiden.
/sʌɪkləʊˈfɒsfəmʌɪd/ Pharmacology.
A fine white crystalline powder used as a cytotoxic drug in the treatment of tumours and some kinds of leukæmia, and usually given intravenously or orally; 2-[di-(2-chloroethyl)-amino-]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide, C7H15Cl2N2O2P.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia
amethopterin1948
Myleran1952
Laetrile1953
thioguanine1953
thioTEPA1953
mercaptopurine1954
methotrexate1955
busulfan1956
chlorambucil1956
cyclophosphamide1960
vinblastine1962
vincristine1962
levamisole1969
vinca alkaloid1970
doxorubicin1971
tamoxifen1972
Airol1974
trastuzumab1997
thiotepa-
1960 Brit. Med. Jrnl. 24 Dec. 1837/1 We report our experiences in the treatment of Hodgkins's disease and other tumours of lymphoreticular tissue with a cyclic nitrogen mustard phosphamide ester, cyclophosphamide.
1963 Times 16 Feb. 5/4 A drug, cyclophosphamide,..killed some of the cells thought to be responsible for rejecting foreign tissue such as the newly grafted kidney.
1966 Lancet 24 Dec. 1382/1 Cyclophosphamide was tried, unsuccessfully, in one patient, but this drug is known to be antagonised by dapsone.
1967 Martindale's Extra Pharmacopoeia (ed. 25) 818/2 The most troublesome side-effect of cyclophosphamide therapy is alopecia.
1969 Nature 1 Feb. 468/2 Cyclophosphamide shows promise as a method of removing the wool from sheep chemically.
1970 Sci. Jrnl. Mar. 63/1 Modern drugs such as methotrexate and cyclophosphamide are extremely valuable in the treatment of many cancers and especially leukaemias.
This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2018).
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n.1960