cryoglobulinn.
/ˌkrʌɪə(ʊ)ˈɡlɒbjᵿlɪn/, U.S. /ˌkraɪoʊˈɡlɑbjələn/ Biochemistry.
An abnormal immunoglobulin, often of monoclonal origin, that separates from serum by precipitation or gelling when the serum is cooled.
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cryoglobulin1947
lectin1954
phytoagglutinin1956
1947 A. B. Lerner & C. J. Watson in Amer. Jrnl. Med. Sci. 214 413/1 The term cryoglobulin is..suggested to represent a group of proteins with the common property of precipitating (or gelifying) from cooled serum.
1965 Oxf. Mag. 25 Feb. 235/2 He perfected a technique for the assay of cryoglobulins, proteins separating from blood at temperatures below that of the body.
2009 D. Meyer & H. C. Bodenheimer in K. Shetty & G. Y. Wu Chronic Viral Hepatitis (ed. 2) 138 The production of cryoglobulins appears to be driven by chronic antigen stimulation of the host immune system by HCV [= hepatitis C virus].
This entry has been updated (OED Third Edition, June 2011; most recently modified version published online March 2022).
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n.1947