cointegraten.

Brit.

/kəʊˈɪntᵻɡrət/, U.S.

/koʊˈɪn(t)əˌɡrət/,

/koʊˈɪn(t)əˌɡreɪt/

Origin: Formed within English, by derivation. Etymons: co- prefix, integrate v.

Etymology: < co- prefix + integrate v.

Molecular Biology.

A circular structure formed as an intermediate in replicative transposition (transposition n. 7), consisting of a donor chromosome, plasmid, or other replicon fused to a recipient replicon by two copies of a transposon, one at each junction.

ΚΠ

1973 C. E. Milliken & R. C. Clowes in Jrnl. Bacteriol. 113 1031/2 We will term these two R factor types as R-factor plasmid aggregates and R-factor plasmid cointegrates, respectively.

1983 J. R. S. Fincham Genetics x. 270 Reciprocal recombination..resolves the cointegrate into two separate plasmids.

1990 EMBO Jrnl. 9 4055/1 Plasmids carrying (IS21 )₂ form cointegrates with other replicons at high frequencies.

2002 N. D. F. Grindley in N. L. Craig et al. Mobile DNA II xiv. 272/1 They transpose by a replicative pathway forming an intermediate, called a cointegrate.., in which the entire donor replicon is inserted into the target DNA with the insert flanked by direct repeats of the transposon.

This is a new entry (OED Third Edition, March 2010; most recently modified version published online March 2022).

单词	cointegrate
释义	cointegraten. Brit. /kəʊˈɪntᵻɡrət/, U.S. /koʊˈɪn(t)əˌɡrət/, /koʊˈɪn(t)əˌɡreɪt/ Origin: Formed within English, by derivation. Etymons: co- prefix, integrate v. Etymology: < co- prefix + integrate v. Molecular Biology. A circular structure formed as an intermediate in replicative transposition (transposition n. 7), consisting of a donor chromosome, plasmid, or other replicon fused to a recipient replicon by two copies of a transposon, one at each junction. ΚΠ 1973 C. E. Milliken & R. C. Clowes in Jrnl. Bacteriol. 113 1031/2 We will term these two R factor types as R-factor plasmid aggregates and R-factor plasmid cointegrates, respectively. 1983 J. R. S. Fincham Genetics x. 270 Reciprocal recombination..resolves the cointegrate into two separate plasmids. 1990 EMBO Jrnl. 9 4055/1 Plasmids carrying (IS21 )₂ form cointegrates with other replicons at high frequencies. 2002 N. D. F. Grindley in N. L. Craig et al. Mobile DNA II xiv. 272/1 They transpose by a replicative pathway forming an intermediate, called a cointegrate.., in which the entire donor replicon is inserted into the target DNA with the insert flanked by direct repeats of the transposon. This is a new entry (OED Third Edition, March 2010; most recently modified version published online March 2022). < n.1973
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