co-enzymen.

Etymology: < German ko-enzym (Buchner and Katte 1908, in Biochem. Zeitschr. VIII. 524), < co- prefix 5b + enzyme n.Previous versions of the OED give the stress as: co-ˈenzyme.

Chemistry.

A non-protein organic compound with which an enzyme needs to combine to become active and which generally takes part in the reaction as a carrier.

ΚΠ

1908 Chem. Abstr. 2568 (title) The co-enzyme of the yeast press-juice.

1936 Chem. Abstr. 6397 A comprehensive treatise discussing..character and action of coenzymes and apoenzymes.

1941 Ann. Reg. 1940 344 Vitamin H proved identical with biotin, a growth factor for yeast, and with coenzyme R.

1947 Thorpe's Dict. Appl. Chem. VIII. 612/2 Coenzymes will be designated by the name of the enzyme activated, preceded by the prefix co- (example, coglyoxylase).

1950 Endeavour 9 145/1 The entire enzyme or holoenzyme is built up of at least two fractions: (a) The apoenzyme, which is always a protein; it is colloidal and thermolabile. (b) The co-enzyme, of variable chemical constitution, frequently a phosphoric ester and sometimes a metallic derivative; very often the co-enzyme, which is non-colloidal, is fairly thermostable.

1961 A. S. MacNalty Brit. Med. Dict. 123/2 Apo-enzyme, the protein carrier, or enzyme proper (e.g. carboxylase) which, with a co-enzyme (co-carboxylase), carries out an enzymic reaction.

Draft additions 1997

coenzyme A n. [ < A- (in acetylation n.] a coenzyme mononucleotide which acts as a carrier of acyl (esp. acetyl) groups, and which is synthesized from pantothenic acid.

ΘΚΠ

the world > matter > chemistry > organic chemistry > substances in fungi > [noun] > co-enzymes

coenzyme A1947

1947 Novelli & Lipman in Arch. Biochem. 14 23 More recently this coenzyme was recognized as a pantothenic acid derivative..for which the term coenzyme A was introduced.

1977 Ann. Internal Med. 86 338/1 Brain acetylcholine is synthesized by combining molecules of choline and of acetyl coenzyme A, a process catalyzed by the enzyme choline acetyltransferase.

1988 BioFactors 1 267/1 Coenzyme A esters are the substrates and regulators of many enzymatic reactions, among them condensations,..acylations, isomerizations and epimerizations.

This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2019).

单词	co-enzyme
释义	co-enzymen. Etymology: < German ko-enzym (Buchner and Katte 1908, in Biochem. Zeitschr. VIII. 524), < co- prefix 5b + enzyme n.Previous versions of the OED give the stress as: co-ˈenzyme. Chemistry. A non-protein organic compound with which an enzyme needs to combine to become active and which generally takes part in the reaction as a carrier. ΚΠ 1908 Chem. Abstr. 2568 (title) The co-enzyme of the yeast press-juice. 1936 Chem. Abstr. 6397 A comprehensive treatise discussing..character and action of coenzymes and apoenzymes. 1941 Ann. Reg. 1940 344 Vitamin H proved identical with biotin, a growth factor for yeast, and with coenzyme R. 1947 Thorpe's Dict. Appl. Chem. VIII. 612/2 Coenzymes will be designated by the name of the enzyme activated, preceded by the prefix co- (example, coglyoxylase). 1950 Endeavour 9 145/1 The entire enzyme or holoenzyme is built up of at least two fractions: (a) The apoenzyme, which is always a protein; it is colloidal and thermolabile. (b) The co-enzyme, of variable chemical constitution, frequently a phosphoric ester and sometimes a metallic derivative; very often the co-enzyme, which is non-colloidal, is fairly thermostable. 1961 A. S. MacNalty Brit. Med. Dict. 123/2 Apo-enzyme, the protein carrier, or enzyme proper (e.g. carboxylase) which, with a co-enzyme (co-carboxylase), carries out an enzymic reaction. Draft additions 1997 coenzyme A n. [ < A- (in acetylation n.] a coenzyme mononucleotide which acts as a carrier of acyl (esp. acetyl) groups, and which is synthesized from pantothenic acid. ΘΚΠ the world > matter > chemistry > organic chemistry > substances in fungi > [noun] > co-enzymes coenzyme A1947 1947 Novelli & Lipman in Arch. Biochem. 14 23 More recently this coenzyme was recognized as a pantothenic acid derivative..for which the term coenzyme A was introduced. 1977 Ann. Internal Med. 86 338/1 Brain acetylcholine is synthesized by combining molecules of choline and of acetyl coenzyme A, a process catalyzed by the enzyme choline acetyltransferase. 1988 BioFactors 1 267/1 Coenzyme A esters are the substrates and regulators of many enzymatic reactions, among them condensations,..acylations, isomerizations and epimerizations. This entry has not yet been fully updated (first published 1972; most recently modified version published online June 2019). < n.1908
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