| 释义 |
stathmokinesis Biol. and Med.|ˌstæθməʊkɪˈniːsɪs|
[ad. F. stathmocinèse (A.-P. Dustin 1938, in Compt. Rend. de l'Assoc. des Anatomistes XXXIII. 209), f. Gr. σταθµό-ς station, stage + κίνησις motion.]
The type of cell division produced by substances such as colchicine, characterized by a halt or long delay at metaphase. Hence ˌstathmokiˈnetic a., (of a drug) that produces stathmokinesis; applied also to the method of measuring rates of cell division by means of such a drug.
1945Bot. Rev. XI. 148 While some cells showed complete pycnosis, normal telophase stages and cytoses occurred. Some cells assumed normal telophase stages and formed giant or polyploid nuclei. Dustin proposed the name of ‘stathmocinesis’ for this type of indirect division and applied the name of ‘stathmocinetic poison’ to colchicine. He contended that the arrest of the nuclear division in the metaphase was preceded by a phase of excitation which distinguished this poison from those which merely inhibited division. 1971Brit. Jrnl. Cancer XXV. 692 Since the stathmokinetic method we used cannot provide information about the proportion of cells actually in the proliferative cycle, the proportion or index of arrested metaphases..can only be used to find the potential doubling time..of the tumour cell population. 1977W. A. Aherne et al. Introd. Cell Population Kinetics iii. 18 (heading) Metaphase arrest (stathmokinesis). Ibid., The stathmokinetic agents in use today are colchicine, its derivative Colcemid, and the increasingly popular vinca alkaloids vinblastine and vincristine. |