| 释义 |
Creutzfeldt–Jakob, n. Path.|ˌkrɔɪtsfɛltˈjækɒb|
Also (misspelt) Creutzfeld–Jakob.
[The names of Hans G. Creutzfeldt (1885–1964) and Alfons M. Jakob (1882–1927), German neurologists. Cf. earlier Ger. Creutzfeldt–Jakobsche Krankheit.]
Used attrib. and in the possessive, usu. in Creutzfeldt–Jakob disease, to designate a communicable progressive disease of the human brain, caused by a prion, in which the degeneration and loss of neurones result in dementia and loss of mobility, and which is accompanied by histological changes characteristic of other spongiform encephalopathies.
1939Q. Cumulative Index Medicus XXIV. 1047/1 (title) Creutzfeldt-Jakob's disease (spastic pseudosclerosis). 1957Jrnl. Neuropath. & Exper. Neurol. XVI. 134 Several years ago I had the opportunity of studying the microscopical sections of a Norwegian case of Creutzfeld-Jakob disease. 1963Jrnl. Neuropath. & Exper. Neurol. XXII. 381 Creutzfeldt-Jakob's disease..shares the following clinical features with Alzheimer's and Pick's diseases. 1985Times 8 Nov. 13/7 A suspicion that the hormone..might be a source of the virus which causes Creutzfeld-Jakob disease. 1987Economist 14 Nov. 94/1 Others [sc. examples of slow-virus diseases] include Creutzfelt-Jakob [sic] syndrome and Gerstmann-Straussler syndrome, both mercifully rare. 1993Guardian 30 Oct. 8/8 He argues that, if man is susceptible to BSE, then at least 8 million adults are likely to have eaten enough to get Creutzfeldt-Jakob Disease (the human form) unless they die first from other causes. 1996Daily Telgraph 25 Mar. 1 Douglas Hogg, the Agriculture Minister, confirmed his department was actively considering several slaughter options to combat the renewed threat of BSE in the wake of the announcement last week of a possible link with Creutzfeld-Jakob Disease in humans. |