| 释义 |
colicin Bacteriol.|ˈkɒlɪsɪn|
Also -ine |-iːn|.
[a. F. colicine (Gratia & Fredericq 1946, in Compt. Rend. Soc. de Biol. CXL. 1032), f. coli + -c-: see -in1, -ine5.]
Any of a group of antibiotic agents, mostly proteins, which are produced by some coliform bacteria, usually in response to an external stimulus, and are effective against other strains of bacteria in the same family.
1946Heatley & Florey in Brit. Jrnl. Exper. Path. XXVII. 380 It is understood that the production of several different inhibitors (named ‘colicines’) by strains of Bact. coli has been proved... Professor Gratia has kindly examined the Bact. coli strain CF1 used in this work, and reports that it appears to be identical..with his Coli V... We are adopting his generic name ‘colicine’ for our substance. 1947Jrnl. Bacteriol. LIV. 785 Antibiotic strains of E. coli are not at all infrequent... The antibiotic substances produced, to which was assigned the term ‘colicin’..differ not only in their antibiotic spectra but also in their physicochemical properties. 1961Nature 10 June 986 Salmonella typhimurium strain LT2 does not form and is not killed by colicines E1, E2, I or K. However, it can be made colicinogenic for any of these colicines by growth in mixed culture with an appropriate..strain of Enterobacter, presumably as a result of the transfer of a genetic element (colicine factor) controlling the production of a particular colicine. 1973R. G. Krueger et al. Introd. Microbiol. xv. 424/2 Colicin production is lethal to a cell in which it occurs, but the colicin molecules released by cell lysis do not affect other cells in the population carrying the same col factor. 1978Nature 9 Nov. 159/1 Colicins, bactericidal proteins (MW 50,000–100,000) produced by Escherichia coli, are of three major functional types.
Hence ˌcolicinoˈgenic a., having or conferring the ability to produce a colicin; coliciˈnogeny, the production of a colicin by a bacterium.
1955Biochim. & Biophys. Acta XVIII. 131 Usually colicinogenic strains do not produce activity against themselves. 1960B. A. D. Stocker in Hayes & Clowes Microbial Genetics 6 Some recent observations on colicinogeny in Salmonella typhimurium. 1961[see colicin]. 1970Nature 12 Dec. 1032/1 The colicinogenic factor of Escherichia coli. 1973R. G. Krueger et al. Introd. Microbiol. xv. 424/2 Colicinogeny has been the subject of considerable study and there are resemblances between this phenomenon and lysogeny. 1976Ann. Rev. Microbiol. XXX. 134 Exclusion occurs among different colicinogenic plasmids and sex factors of E. coli as well as in viral systems. 1984Jrnl. Hygiene XCIII. 79 This paper reports the presence of multiple drug resistance and colicinogeny in the epidemic S. agona strain. |