| 释义 |
quinazoline Chem.|kwɪˈnæzəliːn|
[ad. G. chinazolin (A. Weddige 1887, in Jrnl. f. prakt. Chem. XXXVI. 142), f. chinolin quinoline with inserted az- (see azo-).]
A yellow, basic, crystalline solid, C8H6N2, which has a bicyclic structure formed from fused benzene and pyrimidine rings; any substituted derivative of this.
1887Jrnl. Chem. Soc. LII. ii. 1044 Anhydroacetyl⁓orthamidobenzamide is regarded as a derivative of a hypothetical base, quinazoline,..isomeric with cinnoline and quinoxaline. 1903Ibid. LXXXIV. i. 446 By oxidising this base with potassium ferricyanide, quinazoline..was at last successfully prepared; it..crystallises from light petroleum in glistening flakes resembling naphthalene, has a bitter, burning taste, and..is odourless at the ordinary temperature. 1926H. G. Rule tr. J. Schmidt's Text-bk. Org. Chem. 700 Quinazolines..are strong bases, which are readily reduced to their dihydro-compounds. 1950Thorpe's Dict. Appl. Chem. (ed. 4) X. 346/2 A variety of substituted quinazolines have been prepared recently as part of the search for effective antimalarials. 1968L. A. Paquette Princ. Mod. Heterocyclic Chem. ix. 326 Quinazoline 3-oxide..shows the same reactivity as quinazoline toward nucleophilic reagents, but the addition products frequently eliminate water with the net effect that 4-substituted quinazoline results. |