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coagulation|kəʊægjʊˈleɪʃən|
[a. F. coagulation (15th c. in Littré) or its source L. coāgulatiōn-em (Pliny), f. coāgulā-re to coagulate.]
1. a. The action or process of coagulating (as it takes place in albumen, blood, milk, etc.); clotting, curdling, ‘setting’.
1477Norton Ord. Alch. in Ashm. v. (1652) 63 Coagulation is noe forme substantiall, But onlie passion of things materiall. 1646Sir T. Browne Pseud. Ep. ii. iv. 82 There will ensue a coagulation, like that of whites of egges. 1804Abernethy Surg. Obs. 112 The closure of the artery above by the coagulation of the blood. 1882Syd. Soc. Lex., Coagulation, term applied to that setting, solidification, or conversion into a tremulous jelly-like substance, which occurs in various animal and vegetable fluids shortly after being shed, and exposed to ordinary temperature.
b. concr. A coagulated mass.
1683Robinson in Ray's Corr. (1848) 138 Volatile alkalies..free the blood from coagulations. 1727Bradley Fam. Dict. s.v. Acid, If the Acid is weak, the Coagulation will only acquire a soft Consistence, as it happens in Milk curdled with the Rennet.
2. More generally.
†a. Solidification by evaporation; deposition of solid matter from solution, as in crystallization. Obs.
1605Timme Quersit. ii. i. 102 Admirable things..are to be discerned..in the preparation [of salt]..so great variety of colours, or the coagulations when the spirit returneth into the body. 1641French Distill. i. (1651) 9 Coagulation, is the reducing of any liquid thing to a thicker substance by evaporating the humidity. 1666Phil. Trans. I. 29 Dissolutions and Coagulations of several Crystallizing Salts. 1718J. Chamberlayne Relig. Philos. (1730) II. xiii. §11 A Precipitation or Coagulation.
†b. Condensation (of vapour, etc.). Obs.
1669Worlidge Syst. Agric. xiv. §1 (1681) 292 The same density or coagulation of the Air represents the Matutine or Vespertine Sun or Moon larger unto our sight than at other times. 1794G. Adams Nat. & Exp. Philos. IV. lii. 452 So extraordinary a coagulation and congelation in the watery clouds.
†c. Coagulated or solidified state. Obs.
1677Hale Prim. Orig. Man. 298 The Water..mingled it self..with the superficies of the Terrestrial sediment..so far as it could pierce, until it were excluded by the denser coagulation of the Earth.
3. a. The act or process of forming or uniting into a mass; concretion, cohesion.
1610Healey St. Aug. Citie of God xi. v. (1620) 391 Hee [Epicurus] makes all his worlds of the casuall coagulation of atomes. 1750tr. Leonardus' Mirr. Stones 23 Inducing the form of the stone by the help of terrestrial coagulation.
b. fig.
1622T. Scott Belg. Pismire 28 Not that heereby I intend to disparage the Nobilitie..but rather to preserve it intire from mixture and coagulation. 1864Kirk Chas. Bold II. iv. ii. 250 Everywhere but in France the process of coagulation was..locally confined.
c. concr. A mass formed by concretion.
1664Evelyn Diary (1857) I. 402 It looked like a fungus..yet was a concretion, or coagulation, of some other matter.
fig.1865Masson Rec. Brit. Philos. (1877) 218 A..coagulation of phenomena which may be called feelings.
4. attrib.: coagulation necrosis [ad. G. coagulationsnecrose (J. Cohnheim Vorlesungen über allg. Path. (1877) I. 453, 473)], a type of necrosis in which dead tissue becomes swollen and firmer and the cells retain their general structure as a result of the coagulation of cytoplasmic proteins; also called coagulative necrosis; coagulation time, the time taken for blood to coagulate after being taken from the body, or for blood plasma to coagulate after a coagulant has been added to counteract an anti-coagulant; cf. clotting time.
1883J. Coats Man. Path. 104 Coagulation necrosis is a term which has recently come into use. 1954E. P. Abraham in H. Florey Lect. Gen. Path. viii. 165 True coagulation necrosis is produced by poisons such as phenol..or mercuric chloride, which denature and coagulate the proteins of the cell.
1893Jrnl. Path. & Bacteriol. I. 444 Coagulation time decreases up to a certain minimum (generally to less than 1 minute), i.e. coagulability increases, by increasing additions of calcium chloride to decalcified blood. 1968Dacie & Lewis Pract. Haematol. (ed. 4) x. 268 In haemophilia the whole-blood coagulation time will be normal in about one-third of patients.
▸ coagulation factor n. = clotting factor n. at clotting n. Additions.
1887J. A. Wyeth Text-bk. Surg. v. 54 The presence of the white corpuscles should not be overlooked in seeking for an explanation of stasis, for paraglobulin, the *coagulation factor of the blood, is the normal property of the leucocytes. 1947P. A. Owren Coagulation Blood vi. 230 An account has been given of investigations regarding the individual coagulation factors. 2002Blood Weekly (Nexis) 30 May 12 Hemophilia A is a genetic bleeding disorder caused by the deficiency of blood coagulation Factor VIII. |