| 释义 |
clastogen, n. Genetics.|ˈklæstədʒɛn|
[f. Gr. κλαστός broken in pieces + -ogen.]
An agent that causes breaks in chromosomes.
1970M. W. Shaw in Ann. Rev. Med. XXI. 409 A term was needed for the cumbersome phrase ‘chromosome-breaking agent’... The word ‘chromosomoclastogen’ is suggested... In this article the more euphonious form ‘clastogen’ will be used. Ibid., Certain genes, viruses, and protozoa are examples of biological clastogens. 1975Poultry Sci. LIV. 310 Failure to detect chromosomal aberrations in either group indicated that Aroclor 1242..is not an effective clastogen. 1988Human Genetics LXXX. 135 Spontaneous and clastogen-induced damage was analyzed in cultures of peripheral blood lymphocytes.
So clastoˈgenic a., causing breaks in chromosomes; clastogeˈnicity n.
1970M. W. Shaw in Ann. Rev. Med. XXI. 410 Some chemicals which are clastogenic may also be mutagenic. Ibid. 411 Among the DNA inhibitors, azascrine, mitomycin C, phleomycin, and streptonigrin have been tested for clastogenicity. 1977Mutation Res. XLVII. 183 Most of the in vitro studies performed on the clastogenicity of LSD indicate either suppression of mitosis or enhanced chromosome damage. 1990Mutagenesis V. 588/1 α- Ni3S2 ..presented a significant clastogenic activity which could be made evident in vitro by cytogenetic analysis of cultured human lymphocytes. |