| 释义 |
pteroylglutamic, a. Biochem.|ˌtɛrəʊaɪlgl(j)uːˈtæmɪk|
[f. pteridine + -oyl + glutamic a.]
a. pteroylglutamic acid: any of a series of derivatives of pteroic acid which have a side chain consisting of one or more glutamic acid residues, and include certain members of the vitamin B complex and other animal growth factors; folic acid.
1946R. B. Angier et al. in Science 31 May 669/1 For the compounds formed from p-aminobenzoic acid and p-aminobenzoyl-l(+)-glutamic acid, the names pteroic acid and pteroylglutamic acid are suggested. 1949,1955[see folacin]. 1967Pike & Brown Nutrition iii. 65 At one time both p-aminobenzoic acid and pteroylglutamic acid were considered to be vitamins, but it is now apparent that the species requirement is for one or the other of the two.
b. With inserted prefix indicating the number of glutamic acid residues present, as pteroylmonoglutamic acid (cf. folic acid), etc. Also pteroylpolyglutamic acid.
1946Ann. N.Y. Acad. Sci. XLVIII. 287 Whereas vitamin Bc..contains one glutamic acid residue, vitamin Bc conjugate contains seven. In the system of nomenclature suggested by the authors [sc. C. W. Waller et al.], vitamin Bc conjugate is therefore pteroylheptaglutamic acid. 1954A. White et al. Princ. Biochem. xlix. 1035 Animal tissues contain an enzyme, ‘vitamin Bc conjugase’, which hydrolyzes the naturally occurring pteroylpolyglutamic acid compounds to pteroylmonoglutamic acid and free glutamic acid. 1955Chem. & Engin. News 6 June 2433/1 The pure substance hitherto known as folic acid, folacine, or vitamin Bc shall be named pteroylmonoglutamic acid. Compounds analogous to it but containing several glutamic acid residues united by amide linkages may be named pteroyltriglutamic acid, pteroylheptaglutamic acid, etc. 1970Passmore & Robson Compan. Med. Stud. II. vii. 7/1 Folic acid in therapeutics means synthetic pteroylmonoglutamic acid but the term is sometimes used to embrace all naturally occurring substances with folic acid activity.
Hence ˌpteroylˈglutamate, (a compound or anion of) any of these acids. (Also with inserted prefix.)
1950R. J. Williams et al. Biochem. of B Vitamins C. ii. 290 Both pteroic acid and formylpteroic acid are inactive for L[actobacillus] casei or humans, while pteroylheptaglutamate is inactive for bacteria. 1958Fruton & Simmonds Gen. Biochem. (ed. 2) xxxix. 999 The pteroyltriglutamate and heptaglutamate both occur in nature and are as active as folic acid in the nutrition of higher animals. 1963[see pteroic a.]. 1970R. W. McGilvery Biochem. xviii. 411 (caption) The structure of the vitamin, pteroylglutamate, more commonly known as folate. 1970Passmore & Robson Compan. Med. Stud. II. vii. 7/1 In foods, folates are found free and in conjugated forms, the latter being polyglutamates such as pteroyltriglutamate and pteroylheptaglutamate. |