| 释义 |
prozone Immunol.|ˈprəʊzəʊn|
[Contraction of pro-agglutinoid zone, f. pro-1 + agglutinoid + zone n.]
The range of relative quantities of precipitin (or agglutinin) and antigen within which the expected precipitation (or agglutination) fails to occur when they are mixed; the mixture so produced, usu. containing antibody in excess. Freq. attrib.
[1914H. Zinsser Infection & Resistance vi. 162 In the study of agglutinin and precipitin reactions, phenomena exactly analagous to the Neisser-Wechsberg effect have been noticed, in the case of the agglutinins, the so-called ‘pro-agglutinoid’ zone being a case in point.] 1916Jrnl. Immunol. I. 6 The fourth line in this table represents the so-called prozone in which excess of precipitinogen inhibits precipitation. 1934Zinsser & Bayne-Jones Textbk. Bacteriol. (ed. 7) xvi. 222 The specificity of the prozones is demonstrable in two ways. In the first place, bacteria that have been subjected to the action of serum showing such a prozone, without being agglutinated, will no longer agglutinate when subsequently emulsified in a potent agglutinating serum. Again, absorption of a prozone serum with the homologous bacteria will remove the prozone. 1964D. F. Gray Immunol. xi. 114 The ‘constant antibody’ precipitin reaction illustrates a phenomenon of diagnostic importance that may occur in agglutination tests, viz. the prozone, in which antigen: antibody aggregation is interfered with in the presence of an excess of antigen or of antibody. 1970Passmore & Robson Compan. Med. Stud. II. xxii. 15/2 The prozone phenomenon..is probably due to the stabilizing effects of high protein concentration on the particles; the protein coating increases the net charge of the particles and brings about increased electrostatic repulsion between individual particles, thus opposing the efforts of the antibody molecules to link them together. |