| 释义 |
prazosin Pharm.|ˈpreɪzəʊsɪn|
[Arbitrary pr- (sometimes interpreted as representing piperazine), + azo- + -sin.]
A drug used (as the hydrochloride) in treating hypertension, being a vasodilator whose molecular structure incorporates quinazoline, piperazine, and furyl rings.
1970Jrnl. Clin. Pharmacol. X. 417/1 These data suggest that prazosin hydrochloride is an efficacious agent for the therapy of ambulatory patients with arterial hypertension, particularly when a thiazide diuretic is given in concert. 1974Brit. Med. Jrnl. 11 May 298/1 Prazosin is a new hypertensive drug thought to have a peripheral action involving direct relaxation of vascular smooth muscle and sympathetic blockade. 1978A. S. Nies in Melmon & Morrelli Clin. Pharmacol. (ed. 2) vi. 200/1 Prazosin produces a number of side effects, the most prominent being weakness, dizziness, headache, palpitations and lack of energy... Postural hypotension occurring within two hours of the first few doses of prazosin has resulted in loss of consciousness in some patients. |