| 释义 |
piperoxan, n. Pharm.|pɪpəˈrɒksæn|
Also -oxane |-eɪn|.
[f. piperidine n. + dioxan n.]
An experimental antipsychotic drug with alpha-adrenoceptor blocking properties, which has also been used (usu. as the hydrochloride) in the diagnosis and treatment of phaeochromocytoma; 2-piperidinomethyl-1,4-benzodioxan, C14H19NO2 .
1950Dispensatory U.S.A. (ed. 24, rev. impr.) II. 2016/2 Piperoxane hydrochloride is an adrenergic-blocking agent of short duration of action which has come into use as a diagnostic test to distinguish between essential hypertension and the hypertension due to an epinephrine-secreting tumor (pheochromocytoma). 1950Jrnl. Amer. Med. Assoc. 4 Nov. 829/2 Piperoxan hydrochloride, is believed by Rosenblueth and Cannon to..produce the blocking of the passage of epinephrine to its site of action inside the smooth muscle cell. 1955Lancet 17 Sept. 577/1 Bacq and Fredericq (1934) reported on the action of an allied substance, 2(1-piperidylmethyl)-1:4-benzodioxane hydrochloride (933F),..now known as piperoxan. 1971European Jrnl. Pharmacol. XIV. 98/2 In the present paper, piperoxane, a classical α-adrenergic blocking agent..was shown to antagonize the inhibitory effect of catapresan on vasomotor centres. 1977Lancet 9 July 96/1 Our laboratory findings suggest an antipsychotic effect for a new class of compounds represented by the alpha-adrenergic antagonist, piperoxane. 1988Jrnl. Neurochem. LI. 1373/1 Activation provoked with the α2-adrenergic antagonist piperoxane (60 mg/kg), which at the dose used induced a similar activation of noradrenergic metabolism in the LC [sc. locus cæruleus] as compared with RU24722 (20 mg/kg), did not induce TH [sc. tyrosine hydroxylase] in the LC. |