| 释义 |
orphenadrine Pharm.|ɔːˈfɛnədriːn|
[f. ortho- + -phenadrine (contraction of diphenhydramine).]
A bitter-tasting ortho-methyl derivative of diphenhydramine used (as its white crystalline citrate or hydrochloride) as an antispasmodic, esp. in the treatment of Parkinsonism; (CH3C6H4)CH(C6H5)·O·CH2CH2N(CH3)2.
1957Jrnl. Amer. Med. Assoc. 13 Apr. 1352/1 The new drug, orphenadrine (Disipal) hydrochloride..has proved exceptionally beneficial in the control of..symptoms of Parkinsonism, without increasing tremor. 1963Practitioner Nov. 646 Two cases are recorded in which the distressing symptoms of persistent hiccup were relieved by orphenadrine citrate. 1977Lancet 16 Apr. 858/2 He was put on orphenadrine but because of progressive extra⁓pyramidal disability levodapa with benserazide (‘Mado⁓par’) was prescribed. |