| 释义 |
ˌpharmacogeˈnetics, n. pl. (const. as sing.) Pharm.
[ad. G. pharmakogenetik n. (F. Vogel 1959, in Ergebnisse d. inneren Med. und Kinderheilkunde XII. 117): see pharmaco-, genetic a., and -ic 2.]
The study of the effect of genetic factors on reactions to drugs.
1960Times 11 Nov. 17/2 This development of pharmaco-genetics may affect quite considerably our methods of treating patients. 1962W. Kalow (title) Pharmacogenetics: heredity and the response to drugs. 1965Fingl & Woodbury in Goodman & Gilman Pharmacol. Basis Therapeutics (ed. 3) i. 25/2 The objectives of pharmacogenetics include not only identification of differences in drug effects that have a genetic basis but also development of simple methods by which susceptible individuals can be recognized before the drug is administered. 1974M. C. Gerald Pharmacol. iii. 58 Among the newest subdivisions of pharmacology is that of pharmacogenetics which is the study of the influence of genetic factors on the drug response.
Hence ˌpharmacogeˈnetic a., -geˈneticist.
1962Pharmaceutical Jrnl. CLXXXIX. 282/3 Pharmacogenetic studies. 1970Passmore & Robson Compan. Med. Stud. II. xxxi. 11/1 Not all pharmacogenetic studies are prompted by the occurrence of adverse effects. 1971Sci. News 26 June 439 Some pharmacogeneticists advocate screening individuals who are to receive succinylcholine before surgery for their pseudocholinesterase activity. 1974M. C. Gerald Pharmacol. iii. 59 Pharmacogenetic differences, in part, account for the development of resistant strains of bacteria and insects. |